Abstract | BACKGROUND: OBJECTIVES: To determine the frequency of FII G20210A and FVL polymorphisms as well as protein C and protein S deficiency in a series of patients with RPL compared with control group. PATIENTS AND METHODS: The study group included 90 randomly selected patients with three or more consecutive miscarriages with the same partner in <20 weeks gestation in 2012. The control population consisted of 44 age-matched women with at least one live born children and no history of pregnancy loss. Functional activity of protein C and S, activated protein C resistance, FVL assay by polymerase chain reaction and prothrombin gene mutation were assessed. The polymorphism frequencies were recorded for each group and comparisons were made. RESULTS: The mean functional activity of protein C and protein S were not significantly different between case and control groups (P >0.05). Frequency of protein C deficiency was also not significantly different between the case and control groups (P=0.906), but frequency of protein S deficiency was significantly higher in patients than controls (P=0.03). Genotype pattern of the patients and healthy individuals were not significantly different with regard to either FVL or Prothrombin G20210A (P > 0.05). CONCLUSIONS:
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Authors | Alireza Parand, Jale Zolghadri, Mozhgan Nezam, Abdolreza Afrasiabi, Sezaneh Haghpanah, Mehran Karimi |
Journal | Iranian Red Crescent medical journal
(Iran Red Crescent Med J)
Vol. 15
Issue 12
Pg. e13708
(Dec 2013)
ISSN: 2074-1804 [Print] Estonia |
PMID | 24693393
(Publication Type: Journal Article)
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