Uterine artery embolisation for symptomatic adenomyosis with polyzene F-coated hydrogel microspheres: three-year clinical follow-up using UFS-QoL questionnaire.

Abstract

PURPOSE:

This study was designed to assess midterm outcome of uterine artery embolisation (UAE) for women with therapy-resistant adenomyosis using polyzene F-coated hydrogel microspheres.

METHODS:

Between September 2006 and January 2010, 29 consecutive women with adenomyosis (15 in combination with fibroids) were treated with UAE using polyzene F-coated hydrogel microspheres. Junction zone thickness was assessed with MRI at baseline and 3 months. Women filled out the uterine fibroid symptom and quality of life questionnaire at baseline, 3 months and after a mean clinical follow-up of 37 months (median 35, range 29-64 months).

RESULTS:

At baseline, symptom severity score of 29 women was mean 67 (median 72, range 23-100). At 3 months, this score decreased to mean 22 (median 15, range 0-66) and mean 15 (median 17, range 0-34) at final follow-up. At final follow-up of mean 37 months (median 35, range 29-64 months), 22 of 29 (76 %) patients were asymptomatic. Of these 22 women, 3 underwent a second UAE at 6, 7, and 14 months. The remaining seven patients clinically improved but still had symptoms; one underwent a hysterectomy. There was no difference in outcome between women with pure adenomyosis and women with additional fibroids. The junction zone of 4 women with additional therapy was significantly thicker compared with the remaining 25 patients.

CONCLUSIONS:

In women with therapy resistant adenomyosis, UAE using polyzene F-coated hydrogel microspheres resulted in 3 years preservation of the uterus in 28 of 29 (97 %) with good clinical outcome in the vast majority of patients. Initial thickness of the junction zone is related to additional therapy.

• Authors: R J Nijenhuis, A J Smeets, M Morpurgo, P F Boekkooi, P J H M Reuwer, M Smink, W J van Rooij, P N M Lohle
• Journal: Cardiovascular and interventional radiology (Cardiovasc Intervent Radiol) Vol. 38 Issue 1 Pg. 65-71 (Feb 2015) ISSN: 1432-086X [Electronic] United States
• PMID: 24692030 (Publication Type: Journal Article, Observational Study)

Chemical References

• Hydrogel, Polyethylene Glycol Dimethacrylate

Topics

• Adenomyosis (therapy)
• Adult
• Female
• Follow-Up Studies
• Humans
• Hydrogel, Polyethylene Glycol Dimethacrylate (administration & dosage)
• Microspheres
• Middle Aged
• Prospective Studies
• Quality of Life
• Surveys and Questionnaires
• Treatment Outcome
• Uterine Artery Embolization (methods)