Inhibition of amyloid fibril growth and dissolution of amyloid fibrils by curcumin-gold nanoparticles.

Abstract

Inhibition of amyloid fibrillation and clearance of amyloid fibrils/plaques are essential for the prevention and treatment of various neurodegenerative disorders involving protein aggregation. Herein, we report curcumin-functionalized gold nanoparticles (Au-curcumin) of hydrodynamic diameter 10-25 nm, which serve to inhibit amyloid fibrillation and disintegrate/dissolve amyloid fibrils. In nanoparticle form, curcumin is water-soluble and can efficiently interact with amyloid protein/peptide, offering enhanced performance in inhibiting amyloid fibrillation and dissolving amyloid fibrils. Our results imply that nanoparticle-based artificial molecular chaperones may offer a promising therapeutic approach to combat neurodegenerative disease.

• Authors: Sharbari Palmal, Amit Ranjan Maity, Brijesh Kumar Singh, Sreetama Basu, Nihar R Jana, Nikhil R Jana
• Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (Chemistry) Vol. 20 Issue 20 Pg. 6184-91 (May 12 2014) ISSN: 1521-3765 [Electronic] Germany
• PMID: 24691975 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Amyloid
• Amyloid beta-Peptides
• Gold
• Curcumin

Topics

• Amino Acid Sequence
• Amyloid (antagonists & inhibitors, chemistry, metabolism, ultrastructure)
• Amyloid beta-Peptides (antagonists & inhibitors, chemistry, metabolism, ultrastructure)
• Curcumin (chemistry, pharmacology)
• Gold (chemistry, pharmacology)
• Humans
• Molecular Sequence Data
• Nanoparticles (chemistry, ultrastructure)
• Solubility (drug effects)