Abstract | OBJECTIVE: METHODS: Patients scheduled to undergo cardiac surgery were randomly assigned between three PCA groups ( nefopam, fentanyl or nefopam + fentanyl). Pain was assessed at rest and during movement at 12, 24, 36, 48 and 72 h after surgery using a visual analogue scale (VAS). Total infused PCA volume, number of rescue drug injections, duration of intubation and length of stay in the intensive care unit were recorded. The incidence of adverse effects was noted at 48 h postoperatively. RESULTS: There were no significant between-group differences in VAS score, total PCA infusion volume or number of rescue injections (n = 92 per group). Nausea was significantly more common in the fentanyl group compared with both other groups. CONCLUSIONS: PCA with nefopam alone provides suitable postoperative analgesia after cardiac surgery.
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Authors | Kyungmi Kim, Wook-Jong Kim, Dae-Kee Choi, Yoon Kyung Lee, In-Cheol Choi, Ji-Yeon Sim |
Journal | The Journal of international medical research
(J Int Med Res)
Vol. 42
Issue 3
Pg. 684-92
(Jun 2014)
ISSN: 1473-2300 [Electronic] England |
PMID | 24691459
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav. |
Chemical References |
- Analgesics, Non-Narcotic
- Analgesics, Opioid
- Nefopam
- Fentanyl
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Analgesia, Patient-Controlled
(methods)
- Analgesics, Non-Narcotic
(administration & dosage, adverse effects)
- Analgesics, Opioid
(administration & dosage, adverse effects)
- Cardiac Surgical Procedures
- Double-Blind Method
- Female
- Fentanyl
(administration & dosage, adverse effects)
- Humans
- Intensive Care Units
- Length of Stay
- Male
- Middle Aged
- Nausea
(etiology, physiopathology)
- Nefopam
(administration & dosage, adverse effects)
- Pain Measurement
- Pain, Postoperative
(drug therapy, physiopathology)
- Prospective Studies
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