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Effect of hesperidin and neohesperidin from bittersweet orange (Citrus aurantium var. bigaradia) peel on indomethacin-induced peptic ulcers in rats.

Abstract
Hesperidin and neohesperidin are the major flavanones isolated from bittersweet orange. It was recently reported that they have potent anti-inflammatory effects in various inflammatory models. In the present study, the effects of hesperidin and neohesperidin on indomethacin-induced ulcers in rats and the underlying mechanisms were investigated. Gastric ulcers were induced in rats with a single dose of indomethacin. The effects of pretreatment with hesperidin and neohesperidin were assessed in comparison with omeprazole as reference standard. Ulcer index, gene expression of gastric cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-α), lipid peroxidation product, malondialdhyde (MDA), and reduced glutathione (GSH) content in stomach were measured. Furthermore, gross and histopathological examination was performed. Our results indicated that both hesperidin and neohesperidin significantly aggravated gastric damage caused by indomethacin administration as evidenced by increased ulcer index and histopathological changes of stomach.
AuthorsDalia I Hamdan, Mona F Mahmoud, Michael Wink, Assem M El-Shazly
JournalEnvironmental toxicology and pharmacology (Environ Toxicol Pharmacol) Vol. 37 Issue 3 Pg. 907-15 (May 2014) ISSN: 1872-7077 [Electronic] Netherlands
PMID24691249 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier B.V. All rights reserved.
Chemical References
  • Tumor Necrosis Factor-alpha
  • Malondialdehyde
  • Hesperidin
  • Cyclooxygenase 2
  • Ptgs2 protein, rat
  • Glutathione
  • neohesperidin
  • Indomethacin
Topics
  • Animals
  • Citrus
  • Cyclooxygenase 2 (genetics)
  • Fruit
  • Gastric Mucosa (metabolism)
  • Glutathione (metabolism)
  • Hesperidin (adverse effects, analogs & derivatives, isolation & purification)
  • Indomethacin
  • Male
  • Malondialdehyde (metabolism)
  • Peptic Ulcer (chemically induced, metabolism, pathology)
  • Rats, Wistar
  • Stomach (drug effects, pathology)
  • Tumor Necrosis Factor-alpha (genetics)

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