Comparison of the effects of cetamolol and atenolol on epinephrine- and isoproterenol-induced hypokalemia in anesthetized dogs.

Abstract

Epinephrine-induced hypokalemia is a beta 2-adrenoceptor-mediated effect known to occur in patients after acute myocardial infarction. Cetamolol and atenolol are beta-adrenoceptor antagonists that possess cardioselectivity. They were studied for their ability to inhibit epinephrine- and isoproterenol-induced hypokalemia in anesthetized dogs at equipotent beta 1-adrenoceptor blocking doses. Cetamolol was able to block epinephrine-induced hypokalemia completely, in a dose-related manner, and to block isoproterenol-induced hypokalemia partially. On the other hand, atenolol could produce only partial blockade of epinephrine-induced hypokalemia in a dose-related manner and had essentially no effect on isoproterenol-induced hypokalemia. These results showed that cetamolol was less cardioselective than atenolol and suggest cetamolol would be more beneficial than atenolol in preventing epinephrine-induced hypokalemia in patients who have an acute myocardial infarction.

• Authors: M Klein, R F Stupienski, S Nettler, T Smith, G Oshiro
• Journal: Journal of cardiovascular pharmacology (J Cardiovasc Pharmacol) Vol. 13 Issue 1 Pg. 118-24 (Jan 1989) ISSN: 0160-2446 [Print] United States
• PMID: 2468922 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Acetamides
• Adrenergic beta-Antagonists
• Atenolol
• Isoproterenol
• Potassium
• Epinephrine
• cetamolol

Topics

• Acetamides (pharmacology)
• Adrenergic beta-Antagonists (pharmacology)
• Anesthesia
• Animals
• Atenolol (pharmacology)
• Dogs
• Dose-Response Relationship, Drug
• Epinephrine (pharmacology)
• Female
• Hemodynamics (drug effects)
• Hypokalemia (chemically induced, physiopathology)
• Isoproterenol (pharmacology)
• Male
• Potassium (blood)