Antiproliferative effects of 12-oxoheteronemin vs heteronemin.

Abstract

The antiproliferative activities of 12-oxoheteronemin and heteronemin were evaluated in six cancer cell lines and IC50 values ranging from 0.66 to 1.35 microM were obtained. In four of the cell lines, 12-oxoheteronemin and heteronemin were equipotent; however, in two estrogenic receptor-positive cell lines, heteronemin showed a stronger potency. Both compounds had no overt effects on cell cycle distribution in HeLa cells, but did rapidly initiate apoptosis as evidenced by increased sub-G1 populations of cells and caspase-dependent PARP cleavage.

• Authors: Siriporn Kittiwisut, Cristina C Rohena, Supreeya Yuenyongsawad, Susan L Mooberry, Anuchit Plubrukarn
• Journal: Natural product communications (Nat Prod Commun) Vol. 9 Issue 3 Pg. 359-60 (Mar 2014) ISSN: 1934-578X [Print] United States
• PMID: 24689214 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 12-oxoheteronemin
• Terpenes
• heteronemin

Topics

• Apoptosis (drug effects)
• Cell Proliferation (drug effects)
• Drug Screening Assays, Antitumor
• HeLa Cells
• Humans
• MCF-7 Cells
• Terpenes (pharmacology)