HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effect of HMB/Arg/Gln on the prevention of radiation dermatitis in head and neck cancer patients treated with concurrent chemoradiotherapy.

AbstractOBJECTIVE:
This prospective randomized Phase II study was designed to evaluate the preventive effect of an oral nutrition supplement composed of beta-hydroxy-beta-methylbutyrate, arginine and glutamine (beta-hydroxy-beta-methylbutyrate/arginine/glutamine) on radiation dermatitis in head and neck cancer patients.
METHODS:
Forty patients with histologically proven head and neck cancer, treated with concurrent chemoradiotherapy involving cisplatin were recruited. They were randomly assigned to the beta-hydroxy-beta-methylbutyrate/arginine/glutamine supplement treatment group (Group A) or the control group that received no supplement (Group B). The primary endpoint of this study was the percentage of patients developing ≥Grade 3 dermatitis. The secondary endpoints were the percentage of patients developing ≥Grade 2 dermatitis, and the duration of each grade of dermatitis relative to the observation period.
RESULTS:
The incidence of ≥Grade 3 dermatitis did not differ between the two groups. However, as secondary endpoints of this study, the incidence of ≥Grade 2 dermatitis was lower in Group A than B (62.6 vs. 94.4%; P < 0.05), and the duration of ≥Grade 1 dermatitis was shorter in Group A than B (44.8 vs. 56.7%; P < 0.01), as was the duration of ≥Grade 2 dermatitis (16.5 vs. 26.5%; P < 0.05).
CONCLUSIONS:
Our study indicated that beta-hydroxy-beta-methylbutyrate/arginine/glutamine supplementation was potentially effective in the prevention of radiation dermatitis in head and neck cancer patients.
AuthorsTakayuki Imai, Kazuto Matsuura, Yukinori Asada, Shun Sagai, Katsunori Katagiri, Eiichi Ishida, Daisuke Saito, Rei Sadayasu, Hitoshi Wada, Shigeru Saijo
JournalJapanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 44 Issue 5 Pg. 422-7 (May 2014) ISSN: 1465-3621 [Electronic] England
PMID24688085 (Publication Type: Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Dipeptides
  • Valerates
  • arginyl-glutamine
  • beta-hydroxyisovaleric acid
Topics
  • Adult
  • Aged
  • Antineoplastic Agents (therapeutic use)
  • Chemoradiotherapy (adverse effects)
  • Dietary Supplements
  • Dipeptides (administration & dosage)
  • Female
  • Head and Neck Neoplasms (drug therapy, pathology, radiotherapy, therapy)
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Prospective Studies
  • Radiodermatitis (diagnosis, prevention & control)
  • Radiotherapy Dosage
  • Severity of Illness Index
  • Treatment Outcome
  • Valerates (administration & dosage)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: