Superficial radially resolved fluorescence and 3D photochemical time-dependent model for photodynamic therapy.

Abstract

Photodynamic therapy (PDT) dosimetric tools are crucial for treatment planning and noninvasive monitoring by means of fluorescence. Present approaches consider usually a 1D problem, a simple photochemical process, or a spatially homogeneous photosensitizer. In this work, a radially resolved superficial photosensitizer fluorescence and 3D photochemical time-dependent PDT model are presented. The model provides a time-dependent estimation of tissue fluorescence and the photosensitizer and singlet oxygen 3D concentrations. The model is applied to a basal cell carcinoma treated by Metvix topical photosensitizer protocol. The analysis shows the potentiality in treatment planning and monitoring. The fluorescence results are in agreement with previous measurements.

• Authors: Irene Salas-García, Félix Fanjul-Vélez, José Luis Arce-Diego
• Journal: Optics letters (Opt Lett) Vol. 39 Issue 7 Pg. 1845-8 (Apr 01 2014) ISSN: 1539-4794 [Electronic] United States
• PMID: 24686620 (Publication Type: Journal Article)

Chemical References

• Photosensitizing Agents
• Protoporphyrins
• protoporphyrin IX

Topics

• Carcinoma, Basal Cell (drug therapy, pathology)
• Humans
• Models, Biological
• Photochemical Processes
• Photochemotherapy
• Photosensitizing Agents (chemistry, therapeutic use)
• Protoporphyrins (chemistry, therapeutic use)
• Skin Neoplasms (drug therapy, pathology)
• Spectrometry, Fluorescence
• Time Factors