Abstract | BACKGROUND: Sustained hypotension among patients with end stage renal disease on dialysis (ESRDh) varies from 5.0% to 12.0%. Despite their role in the regulation of blood pressure (BP) corticoadrenal hormones have been poorly investigated. OBJECTIVES: METHODS: Fifty ESRDh and 30 healthy volunteers were studied. In all cases basal blood and saliva were obtained. Synthetic ACTH (25μg) was injected intramuscularly and at 30min saliva was collected. Circulating ACTH, renin, cortisol and aldosterone were measured and steroids were also assessed in saliva by immunoassay. RESULTS: CONCLUSION: Adrenal function should be assessed in ESRDh in order to unmask adrenal insufficient states.
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Authors | Alejandro L Arregger, Estela M L Cardoso, Alfredo Zucchini, Elvira C Aguirre, Alicia Elbert, Liliana N Contreras |
Journal | Steroids
(Steroids)
Vol. 84
Pg. 57-63
(Jun 2014)
ISSN: 1878-5867 [Electronic] United States |
PMID | 24686207
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Aldosterone
- Hydrocortisone
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Topics |
- Adrenal Cortex
(physiopathology)
- Adult
- Aldosterone
(metabolism)
- Female
- Humans
- Hydrocortisone
(metabolism)
- Hypotension
(physiopathology)
- Kidney Failure, Chronic
(physiopathology)
- Male
- Middle Aged
- Saliva
(metabolism)
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