Abstract |
Synovial tissues from patients with ankylosing spondylitis or reactive arthritis were examined by an immunoperoxidase technique, using antisera to synthetic peptides representing antigens shared between HLA-B27.1 and Klebsiella pneumoniae nitrogenase. With either antiserum, all HLA-B27+ patients with synovial inflammation showed strong immunoperoxidase staining in synovial lining cells, vascular endothelium, and infiltrating inflammatory cells. These findings indicate that antigens showing cross-reactivity between HLA-B27.1 and Klebsiella nitrogenase epitopes are strongly expressed within inflamed synovial tissues of HLA-B27+ patients.
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Authors | G Husby, N Tsuchiya, P L Schwimmbeck, A Keat, J A Pahle, M B Oldstone, R C Williams Jr |
Journal | Arthritis and rheumatism
(Arthritis Rheum)
Vol. 32
Issue 4
Pg. 437-45
(Apr 1989)
ISSN: 0004-3591 [Print] United States |
PMID | 2468338
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Epitopes
- HLA-B Antigens
- HLA-B27 Antigen
- Interferon-gamma
- Nitrogenase
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Topics |
- Arthritis
(immunology)
- Cartilage, Articular
(immunology)
- Cross Reactions
- Epitopes
- HLA-B Antigens
(analysis)
- HLA-B27 Antigen
- Humans
- Interferon-gamma
(pharmacology)
- Klebsiella pneumoniae
(enzymology)
- Nitrogenase
(immunology)
- Spondylitis, Ankylosing
(immunology)
- Synovial Fluid
(immunology)
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