Cross-reactive epitope with Klebsiella pneumoniae nitrogenase in articular tissue of HLA-B27+ patients with ankylosing spondylitis.

Abstract

Synovial tissues from patients with ankylosing spondylitis or reactive arthritis were examined by an immunoperoxidase technique, using antisera to synthetic peptides representing antigens shared between HLA-B27.1 and Klebsiella pneumoniae nitrogenase. With either antiserum, all HLA-B27+ patients with synovial inflammation showed strong immunoperoxidase staining in synovial lining cells, vascular endothelium, and infiltrating inflammatory cells. These findings indicate that antigens showing cross-reactivity between HLA-B27.1 and Klebsiella nitrogenase epitopes are strongly expressed within inflamed synovial tissues of HLA-B27+ patients.

• Authors: G Husby, N Tsuchiya, P L Schwimmbeck, A Keat, J A Pahle, M B Oldstone, R C Williams Jr
• Journal: Arthritis and rheumatism (Arthritis Rheum) Vol. 32 Issue 4 Pg. 437-45 (Apr 1989) ISSN: 0004-3591 [Print] United States
• PMID: 2468338 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Epitopes
• HLA-B Antigens
• HLA-B27 Antigen
• Interferon-gamma
• Nitrogenase

Topics

• Arthritis (immunology)
• Cartilage, Articular (immunology)
• Cross Reactions
• Epitopes
• HLA-B Antigens (analysis)
• HLA-B27 Antigen
• Humans
• Interferon-gamma (pharmacology)
• Klebsiella pneumoniae (enzymology)
• Nitrogenase (immunology)
• Spondylitis, Ankylosing (immunology)
• Synovial Fluid (immunology)