Abstract | BACKGROUND: OBJECTIVES: To investigate the association between isocyanate exposure and eNO levels in isocyanate-exposed workers and to elucidate whether eNO acts as a marker of airway inflammation controlling for smoking and atopy in an industry-wide survey. METHODS: Information on estimated personal isocyanate exposure, measured eNO levels, health effects and sensitisation were analysed in 229 workers from a cross-sectional study. Univariate and multiple regression analyses were used to explore the exposure-response relationships between isocyanate exposure and eNO, stratified by smoking and atopy. RESULTS: A marginally significant exposure-response relationship was found between isocyanate exposure and eNO in atopic, non-smokers (p=0.054). eNO was significantly associated with atopy and smoking, bronchial hyper-responsiveness (BHR), work-related conjunctivitis and rhinitis after adjustment for age, gender, atopy and smoking (p<0.05). A borderline significant association was found between eNO and asthma-like symptoms after adjustment for age, gender, atopy and current smoking (p=0.055). In a small group of isocyanate-exposed workers with positive serum-specific immunoglobulin E ( IgE) antibodies to hexamethylene diisocyanate (HDI), elevated eNO levels were clearly exposure related. eNO was associated with the positive specific IgG antibodies to HDI in non-atopic, non-smokers (p=0.03). CONCLUSIONS:
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Authors | Badri Sadat Jonaid, Anjoeka Pronk, Gert Doekes, Dick Heederik |
Journal | Occupational and environmental medicine
(Occup Environ Med)
Vol. 71
Issue 6
Pg. 415-22
(Jun 2014)
ISSN: 1470-7926 [Electronic] England |
PMID | 24683011
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Immunoglobulins
- Isocyanates
- 1,6-hexamethylene diisocyanate
- Nitric Oxide
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Topics |
- Adult
- Asthma
(etiology, immunology, metabolism)
- Biomarkers
(metabolism)
- Conjunctivitis
(metabolism)
- Cross-Sectional Studies
- Exhalation
- Female
- Humans
- Hypersensitivity, Immediate
(metabolism)
- Immunoglobulins
(blood)
- Inflammation
(etiology, metabolism)
- Isocyanates
(adverse effects, immunology)
- Male
- Middle Aged
- Nitric Oxide
(metabolism)
- Occupational Diseases
(etiology, immunology, metabolism)
- Occupational Exposure
(adverse effects)
- Paint
- Rhinitis
(metabolism)
- Smoking
(metabolism)
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