Abstract | PURPOSE: This observational study aims to investigate the effects of tropicamide (0.5%) on corneal biomechanical properties, with the ocular response analyzer (ORA), in healthy individuals. METHODS: Corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc) measurements of 38 (21 female and 17 male) healthy individuals, before and after 30 min of 0.5% tropicamide instillation, were performed by using the ORA. RESULTS: The mean CH, CRF, IOPg and IOPcc measurements of the eyes were 10.2 ± 1.9 mmHg, 10.3 ± 2.1 mmHg, 15.7 ± 3.4 mmHg, 16.4 ± 3.3 mmHg pre- tropicamide, and 10.4 ± 1.7 mmHg, 10.3 ± 2.1 mmHg, 15.3 ± 3.4 mmHg, 15.8 ± 2.7 mmHg post- tropicamide, respectively. The differences between the pre- and post- tropicamide measurements of the eyes were insignificant (p = 0.184, p = 0.659, p = 0.294, p = 0.150, respectively; paired t-test). CONCLUSIONS: A tropicamide instillation does not lead to significant changes in the corneal biomechanical properties. Therefore, it can be used safely in disease, i.e. in the diagnosis and follow-up ORA as it does not cause any change.
|
Authors | Refik Oltulu, Gunhal Satirtav, Orhan Altunkaya, Gulfidan Bitirgen, Mehmet Okka |
Journal | Cutaneous and ocular toxicology
(Cutan Ocul Toxicol)
Vol. 34
Issue 1
Pg. 35-7
(Mar 2015)
ISSN: 1556-9535 [Electronic] England |
PMID | 24678749
(Publication Type: Clinical Trial, Journal Article)
|
Chemical References |
|
Topics |
- Administration, Topical
- Adolescent
- Adult
- Aged
- Cornea
(drug effects, physiology)
- Female
- Healthy Volunteers
- Humans
- Intraocular Pressure
(drug effects)
- Male
- Middle Aged
- Mydriasis
(chemically induced)
- Mydriatics
(pharmacology)
- Tropicamide
(pharmacology)
- Young Adult
|