Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD.

Abstract

Impulsivity is a multidimensional construct, including impulsive decision-making and impulsive action, representing relatively independent neurocircuitries. ADHD is treated with methylphenidate, a drug that binds to dopamine transporters. This study in 24 adult male patients with ADHD shows that dopamine transporter occupancy by methylphenidate in the putamen correlates with improvements in cognitive but not in motor impulsivity.

• Authors: Cleo L Crunelle, Wim van den Brink, Geert Dom, Jan Booij
• Journal: The British journal of psychiatry : the journal of mental science (Br J Psychiatry) Vol. 204 Issue 6 Pg. 486-7 (Jun 2014) ISSN: 1472-1465 [Electronic] England
• PMID: 24676965 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Royal College of Psychiatrists.

Chemical References

• Dopamine Plasma Membrane Transport Proteins
• Dopamine Uptake Inhibitors
• Methylphenidate

Topics

• Adult
• Attention Deficit Disorder with Hyperactivity (drug therapy)
• Dopamine Plasma Membrane Transport Proteins (drug effects)
• Dopamine Uptake Inhibitors (therapeutic use)
• Humans
• Impulsive Behavior (drug effects)
• Male
• Methylphenidate (therapeutic use)
• Treatment Outcome