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Acute immune hematological complication of oxaliplatin. A series of 3 cases.

Abstract
We report a series of three cases of oxaliplatin-related hematological immune reactions. Two patients developed acute immune hemolytic anemia and the third patient had severe thrombocytopenia. One patient had minor undiagnosed hemolysis after the previous chemotherapy cycle and two of our three patients had minor allergic signs just before the hemolysis. Fifteen cases of immune hemolytic anemia have been reported in the literature, of which only the first was fatal. One case of hemolytic uremic syndrome has been described. Anemia in cancer patients is not always related to myelosuppression and hemolytic anemia can be a severe side effect of oxaliplatin administration.
AuthorsSylvain Garciaz, Sandrine Oziel-Taieb, Slimane Dermeche, Pauline Ries, Julie Vessaud, Jean-Luc Raoul
JournalTumori (Tumori) 2014 Jan-Feb Vol. 100 Issue 1 Pg. e17-9 ISSN: 2038-2529 [Electronic] Italy
PMID24675502 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Organoplatinum Compounds
  • oxaliplatin
  • Leucovorin
  • Fluorouracil
Topics
  • Acute Disease
  • Adenocarcinoma (drug therapy)
  • Aged
  • Anemia, Hemolytic (chemically induced, diagnosis)
  • Antineoplastic Agents (administration & dosage, adverse effects)
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
  • Colonic Neoplasms (drug therapy)
  • Diagnosis, Differential
  • Female
  • Fluorouracil (administration & dosage)
  • Humans
  • Leucovorin (administration & dosage)
  • Liver Neoplasms (drug therapy)
  • Lung Neoplasms (drug therapy)
  • Male
  • Middle Aged
  • Neoplasms (drug therapy)
  • Organoplatinum Compounds (administration & dosage, adverse effects)
  • Rectal Neoplasms (drug therapy)

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