The role of 18F-FDG-PET and PET/CT in patients with colorectal liver metastases undergoing selective internal radiation therapy with yttrium-90: a first evidence-based review.

Abstract

PURPOSE:

To provide a first evidence-based review of the literature on the role of fluorine-18-fluorodeoxyglucose positron emission tomography and positron emission tomography/computed tomography (FDG-PET and PET/CT) in patients with colorectal liver metastases (CRLM) undergoing selective internal radiation therapy (SIRT) with yttrium-90 ((90)Y) microspheres.

METHODS:

A comprehensive computer literature search was conducted to find relevant published articles on whole-body FDG-PET or PET/CT in patients with CRLM undergoing SIRT.

RESULTS:

We identified 19 studies including 833 patients with CRLM undergoing SIRT. The role of FDG-PET or PET/CT was analysed in treatment planning, treatment response evaluation, and as prognostic tool.

CONCLUSION:

FDG-PET and PET/CT provide additional information in treatment evaluation of CRLM patients treated with SIRT and may have a role in treatment planning and patient selection. FDG-PET/CT is emerging as good prognostic tool in these patients.

• Authors: Salvatore Annunziata, Giorgio Treglia, Carmelo Caldarella, Federica Galiandro
• Journal: TheScientificWorldJournal (ScientificWorldJournal) Vol. 2014 Pg. 879469 ( 2014) ISSN: 1537-744X [Electronic] United States
• PMID: 24672385 (Publication Type: Journal Article, Meta-Analysis, Review)

Chemical References

• Yttrium Radioisotopes
• Fluorodeoxyglucose F18

Topics

• Colorectal Neoplasms (pathology)
• Fluorodeoxyglucose F18
• Humans
• Liver Neoplasms (diagnosis, mortality, radiotherapy, secondary)
• Positron-Emission Tomography
• Prognosis
• Tomography, X-Ray Computed
• Treatment Outcome
• Yttrium Radioisotopes