pH-Responsive and near-infrared-emissive polymer nanoparticles for simultaneous delivery, release, and fluorescence tracking of doxorubicin in vivo.

Abstract

Dextran modified with pendant acetals is used to load doxorubicin (DOX) and a near-infrared-emissive conjugated polymer (BTTPF), and this aims to provide selective drug release at therapeutic targets including tumors. The BTTPF is applicable to tracking the anticancer drug release through the change of Förster resonance energy transfer efficiency between doxorubicin and BTTPF during degradation of the nanoparticles in vivo.

• Authors: Ji-Cheng Yu, Yu-Lei Chen, Yu-Qi Zhang, Xi-Kuang Yao, Cheng-Gen Qian, Jun Huang, Sha Zhu, Xi-Qun Jiang, Qun-Dong Shen, Zhen Gu
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 50 Issue 36 Pg. 4699-702 (May 11 2014) ISSN: 1364-548X [Electronic] England
• PMID: 24671329 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fluorescent Dyes
• Polymers
• Doxorubicin

Topics

• Animals
• Doxorubicin (administration & dosage, analysis, pharmacokinetics)
• Drug Delivery Systems (methods)
• Fluorescence Resonance Energy Transfer (methods)
• Fluorescent Dyes (administration & dosage, analysis, pharmacokinetics)
• Hydrogen-Ion Concentration
• Mice
• Nanoparticles (administration & dosage, analysis, metabolism)
• Polymers (administration & dosage, analysis, pharmacokinetics)
• Spectroscopy, Near-Infrared (methods)
• Xenograft Model Antitumor Assays (methods)