NADPH oxidase 1 and its derived reactive oxygen species mediated tissue injury and repair.

Abstract

Reactive oxygen species are mostly viewed to cause oxidative damage to various cells and induce organ dysfunction after ischemia-reperfusion injury. However, they are also considered as crucial molecules for cellular signal transduction in biology. NADPH oxidase, whose only function is reactive oxygen species production, has been extensively investigated in many cell types especially phagocytes. The deficiency of NADPH oxidase extends the process of inflammation and delays tissue repair, which causes chronic granulomatous disease in patients. NADPH oxidase 1, one member of the NADPH oxidase family, is not only constitutively expressed in a variety of tissues, but also induced to increase expression in both mRNA and protein levels under many circumstances. NADPH oxidase 1 and its derived reactive oxygen species are suggested to be able to regulate inflammation reaction, cell proliferation and migration, and extracellular matrix synthesis, which contribute to the processes of tissue injury and repair.

• Authors: Xiu-Jun Fu, Ying-Bo Peng, Yi-Ping Hu, You-Zhen Shi, Min Yao, Xiong Zhang
• Journal: Oxidative medicine and cellular longevity (Oxid Med Cell Longev) Vol. 2014 Pg. 282854 ( 2014) ISSN: 1942-0994 [Electronic] United States
• PMID: 24669283 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Reactive Oxygen Species
• NADH, NADPH Oxidoreductases
• NADPH Oxidase 1

Topics

• Animals
• Epithelial Cells (enzymology, pathology)
• Extracellular Matrix (metabolism)
• Humans
• Inflammation (pathology)
• NADH, NADPH Oxidoreductases (metabolism)
• NADPH Oxidase 1
• Reactive Oxygen Species (metabolism)
• Wound Healing