Luteolin protects against high fat diet-induced cognitive deficits in obesity mice.

Abstract

The epidemic and experimental studies have confirmed that the obesity can lead to neuroinflammation, neurodegenerative diseases and adversely affect cognition. Despite the numerous elucidations on the impact of obesity on cognition decline, the contributors to the impairments in obesity remain unclear. Male C57BL/6J mice were fed either a control or high-fat diet (HFD) for 16 weeks and then randomized into four groups treated with their respective diets for 4 weeks including control diet (CD); control diet+luteolin (CDL); high-fat diet (HFD), high-fat diet+luteolin (HFDL). The dose of luteolin was 10mg/kg, oral. We showed that adding luteolin in high-fat diet can significantly reduce body weight gain, food intake and plasma cytokines as well as improving glucose metabolism of mice on HFD. Importantly, we showed that luteolin treatment had the effects of alleviating neuroinflammation, oxidative stress and neuronal insulin resistance in the mouse brain, restored blood adipocytokines level to normal. Furthermore, luteolin increased the level of brain-derived neurotrophic factor (BDNF), the action of synapsin I (SYP) and postsynaptic density protein 95 (PSD-95) in the cortex and hippocampus as to that the behavioral performance in Morris water maze (MWM) and step-through task were significantly improved. These results indicate a previously unrecognized potential of luteolin in alleviating obesity-induced cognitive impairment for type-2 diabetes mellitus and Alzheimer disease (AD).

• Authors: Yi Liu, Xiaobin Fu, Nuo Lan, Sai Li, Jingzheng Zhang, Shuaishuai Wang, Cheng Li, Yanguo Shang, Tonghui Huang, Ling Zhang
• Journal: Behavioural brain research (Behav Brain Res) Vol. 267 Pg. 178-88 (Jul 01 2014) ISSN: 1872-7549 [Electronic] Netherlands
• PMID: 24667364 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Adipokines
• Anti-Obesity Agents
• Blood Glucose
• Brain-Derived Neurotrophic Factor
• Cytokines
• Disks Large Homolog 4 Protein
• Dlg4 protein, mouse
• Membrane Proteins
• Synapsins
• Guanylate Kinases
• Luteolin

Topics

• Adipokines (blood)
• Animals
• Anti-Obesity Agents (pharmacology)
• Blood Glucose (metabolism)
• Brain (drug effects, pathology, physiopathology)
• Brain-Derived Neurotrophic Factor (metabolism)
• Cognition Disorders (etiology, pathology, physiopathology, prevention & control)
• Cytokines (blood)
• Diet, High-Fat (adverse effects)
• Disks Large Homolog 4 Protein
• Eating (drug effects)
• Guanylate Kinases (metabolism)
• Insulin Resistance (physiology)
• Luteolin (pharmacokinetics)
• Male
• Maze Learning (drug effects, physiology)
• Membrane Proteins (metabolism)
• Mice, Inbred C57BL
• Neuroimmunomodulation (drug effects, physiology)
• Neurons (drug effects, pathology, physiology)
• Obesity (complications, drug therapy, pathology, physiopathology)
• Oxidative Stress (drug effects, physiology)
• Synapsins (metabolism)
• Weight Gain (drug effects)