HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Immunological monitoring of endogenous attack-like psychoses].

Abstract
To analyze the possibility of using immunological parameters for the assessment of the activity of the process and prediction of the quality and completion of remission, we compared the dynamics of clinical and immunological parameters in 76 patients with endogenous attack-like psychoses during pharmacotherapy of a psychotic episode. Authors confirmed evidence for the activation of innate and adaptive immunity in the acute stage of psychosis as well as the correlation between immunological parameters (leukocyte elastase (LE) activity, alpha(1)-proteinase inhibitor (alpha(1)-PI), the level of autoantibodies to nerve growth factor (Aab-NGF)) and clinical symptoms assessed with the PANSS. The improvement of the clinical state assessed by the reduction in PANSS total score was noted in all patients though there were variations in the dynamics of immunological parameters. The increase of immunological parameters, along with the absence of changes at the discharge from the hospital, suggests that the remission was of low quality and the pathological process did not attenuate. Outpatient examination revealed the different dynamics of psychopathological disorders: stable state in 50% patients, moderate worsening of psychological state in 50% patients. Worsening of clinical symptoms after the discharge and in the outpatient stage was correlated with the elevation of the activity/level of immunological parameters. The changes in LE activity and Aab-NGF level precede the changes in mental state of patients in the following 1-2 months. These parameters may be used for monitoring of patients and prediction of quality and completion of remission.
AuthorsT P Kliushnik, S A Zozulia, L V Androsova, Z V Sarmanova, I N Otman, A M Dupin, G P Panteleeva, I V Oleĭchik, L I Abramova, S A Stoliarov, E S Shipilova, O A Borisova
JournalZhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 114 Issue 2 Pg. 37-41 ( 2014) ISSN: 1997-7298 [Print] Russia (Federation)
PMID24662343 (Publication Type: English Abstract, Journal Article)
Chemical References
  • alpha 1-Antitrypsin
  • Nerve Growth Factor
  • Leukocyte Elastase
Topics
  • Adaptive Immunity
  • Adult
  • Aged
  • Female
  • Humans
  • Leukocyte Elastase (immunology)
  • Male
  • Middle Aged
  • Monitoring, Immunologic
  • Nerve Growth Factor (immunology)
  • Prognosis
  • Psychotic Disorders (diagnosis, immunology)
  • Young Adult
  • alpha 1-Antitrypsin (immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: