Abstract | BACKGROUND: METHODS: Immunohistochemical staining for Tiam1 was performed on 98 adenocarcinoma and 30 normal lung tissues. The association of Tiam1 protein expression with the clinicopathological characteristics and the prognosis of lung adenocarcinoma were subsequently assessed. RESULTS: Immunohistochemical analysis showed that 60 of 98 (61.22%) adenocarcinoma tissues showed high expression of Tiam1, and high Tiam1 expression was significantly associated with advanced TNM stage (P < 0.0005) and lymph node status (P < 0.0005) of lung adenocarcinoma. Moreover, the lung adenocarcinoma patients with low Tiam1 expression had higher overall survival than patients with high Tiam1 expression (log rank value = 10.805, P = 0.001). High expression of Tiam1 predicted poor overall survival of patients in stages I + II (P = 0.006). Furthermore, multivariate analysis indicated that high expression of Tiam1 protein was an independent prognostic factor for overall survival (P = 0.011) in patients with lung adenocarcinoma. CONCLUSION: VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1377798917111123.
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Authors | Shuguang Liu, Yumei Li, Wenjuan Qi, Yunfei Zhao, Aili Huang, Wenjie Sheng, Bin Lei, Peixin Lin, Haili Zhu, Wenxia Li, Hong Shen |
Journal | Diagnostic pathology
(Diagn Pathol)
Vol. 9
Pg. 69
(Mar 24 2014)
ISSN: 1746-1596 [Electronic] England |
PMID | 24661909
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Guanine Nucleotide Exchange Factors
- T-Lymphoma Invasion and Metastasis-inducing Protein 1
- TIAM1 protein, human
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Topics |
- Adenocarcinoma
(metabolism, mortality, pathology)
- Adenocarcinoma of Lung
- Adult
- Aged
- Biomarkers, Tumor
(analysis)
- Female
- Guanine Nucleotide Exchange Factors
(analysis, biosynthesis)
- Humans
- Immunohistochemistry
- Kaplan-Meier Estimate
- Lung Neoplasms
(metabolism, mortality, pathology)
- Lymphatic Metastasis
(pathology)
- Male
- Middle Aged
- Prognosis
- Proportional Hazards Models
- T-Lymphoma Invasion and Metastasis-inducing Protein 1
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