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Granulocytic sarcoma: misleading immunohistological staining with MT1 and S100 protein antibodies.

Abstract
Tissue from two patients with granulocytic sarcomas stained positively for MT1 and S100 protein antibodies; both of these cases presented considerable clinical and histological diagnostic difficulties until acute myeloblastic leukaemia spread to the bone marrow. Tissues from a further eight patients with granulocytic sarcoma were also examined retrospectively. Seven of them stained for MT1 and four for S100 protein but the traditional histological markers for myeloid cells--chloroacetate esterase and lysosyme--often stained only weakly and focally. This pattern of staining should raise the possibility of a granulocytic sarcoma in otherwise problematic cases.
AuthorsC J Elliott, K P McCarthy, R L Carter, P Davies
JournalJournal of clinical pathology (J Clin Pathol) Vol. 42 Issue 2 Pg. 188-90 (Feb 1989) ISSN: 0021-9746 [Print] England
PMID2466055 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibodies, Monoclonal
  • S100 Proteins
Topics
  • Adult
  • Antibodies, Monoclonal (analysis)
  • Female
  • Humans
  • Leukemia, Myeloid (diagnosis)
  • Male
  • Middle Aged
  • S100 Proteins (analysis)
  • Staining and Labeling

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