Abstract |
Tissue from two patients with granulocytic sarcomas stained positively for MT1 and S100 protein antibodies; both of these cases presented considerable clinical and histological diagnostic difficulties until acute myeloblastic leukaemia spread to the bone marrow. Tissues from a further eight patients with granulocytic sarcoma were also examined retrospectively. Seven of them stained for MT1 and four for S100 protein but the traditional histological markers for myeloid cells-- chloroacetate esterase and lysosyme--often stained only weakly and focally. This pattern of staining should raise the possibility of a granulocytic sarcoma in otherwise problematic cases.
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Authors | C J Elliott, K P McCarthy, R L Carter, P Davies |
Journal | Journal of clinical pathology
(J Clin Pathol)
Vol. 42
Issue 2
Pg. 188-90
(Feb 1989)
ISSN: 0021-9746 [Print] England |
PMID | 2466055
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- S100 Proteins
|
Topics |
- Adult
- Antibodies, Monoclonal
(analysis)
- Female
- Humans
- Leukemia, Myeloid
(diagnosis)
- Male
- Middle Aged
- S100 Proteins
(analysis)
- Staining and Labeling
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