Inhibitory effect of the plant Clusia fluminensis against biological activities of Bothrops jararaca snake venom.

Abstract

The ability of extracts of the plant Clusia fluminensis Planch & Triana (Clusiaceae Lindl.) to neutralize proteolysis, clotting, hemolysis, hemorrhagic and lethality activities of Bothrops jararaca snake venom was studied. Clusianone and lanosterol from the flower and fruit extracts, respectively, were also tested. The extracts of different organs of C. fluminensis inhibited proteolysis and hemolysis induced by B. jararaca venom, but with different potencies. Only the stems prevented blood clotting. Only the acetone extract of the fruit protected mice from hemorrhage while the acetone or methanol extracts prevented mice from death. Clusianone and lanosterol did not inhibit clotting or hemorrhage, but the former inhibited proteolysis and the latter hemolysis.

• Authors: Eduardo Coriolano de Oliveira, Maria Carolina Anholeti, Thaisa Francielle Domingos, Camila Nunes Faioli, Eladio Flores Sanchez, Selma Ribeiro de Paiva, André Lopes Fuly
• Journal: Natural product communications (Nat Prod Commun) Vol. 9 Issue 1 Pg. 21-5 (Jan 2014) ISSN: 1934-578X [Print] United States
• PMID: 24660453 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antivenins
• Crotalid Venoms
• Plant Extracts

Topics

• Animals
• Antivenins (analysis)
• Bothrops
• Clusia (chemistry)
• Crotalid Venoms (antagonists & inhibitors)
• Humans
• Male
• Mice
• Plant Extracts (pharmacology)