Abstract | BACKGROUND: OBJECTIVES: PATIENTS AND METHODS: This double blind randomized clinical trial was conducted on arthroscopic surgery candidates. Participants were randomly allocated to interventions and assigned to two groups of Dextromethorphan and placebo. In Dextromethorphan group, the patients received 1 mg/kg Dextromethorphan orally the night before the operation. Pain severity based on the visual analog scale (VAS) up to 16 hours postoperation, use of opioids, and the first request for analgesics were recorded postoperatively. RESULTS: A total of 112 patients in the Dextromethorphan (n = 54) and placebo groups (n = 58) were evaluated. No significant difference was detected between the two groups for age, sex or ASA. The mean amount of opioid consumption was significantly lower in patients who received Dextromethorphan (10.7 ± 5.6 mg) compared to the placebo group (13.1 ± 5.6 mg), (P = 0.03). The mean time until the first opioid request in patients who received Dextromethorphan was longer than that in the placebo group (P = 0.01). CONCLUSIONS:
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Authors | Saeid Reza Entezary, Saeedeh Farshadpour, Mahmood Reza Alebouyeh, Farnad Imani, Mohammad Kazem Emami Meybodi, Habibollah Yaribeygi |
Journal | Anesthesiology and pain medicine
(Anesth Pain Med)
Vol. 4
Issue 1
Pg. e11187
(Feb 2014)
ISSN: 2228-7523 [Print] Netherlands |
PMID | 24660143
(Publication Type: Journal Article)
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