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A pilot comparison of limited versus large fluid volume resuscitation in canine spontaneous hemoperitoneum.

Abstract
Treatment for hemorrhagic shock secondary to a spontaneous hemoperitoneum includes restoration of IV volume and surgical control of hemorrhage. This study was designed to determine if limited fluid volume resuscitation (LFVR) with hypertonic saline (HS) and hyperoncotic fluids (hydroxyethylstarch [HES]) results in more rapid cardiovascular stabilization in dogs with spontaneous hemoperitoneum versus conventional resuscitation (CR) with large volume resuscitation. Eighteen client-owned dogs presenting in hemorrhagic shock with a spontaneous hemoperitoneum were enrolled. Dogs were randomized to be fluid resuscitated with up to 90 mL/kg of an isotonic crystalloid (CR group) or up to 8 mL/kg of 7.2% Na chloride (i.e., HS) combined with up to 10 mL/kg of 6% HES. Measurements of vital signs, lactate, packed cell volume (PCV), total solids (TS), and blood pressure were made at standard time points. The primary end point was time to stabilization of hemodynamic parameters (measured in min). Dogs in the LFVR group achieved hemodynamic stabilization significantly faster (20 min; range, 10-25 min) than those in the CR group (35 min; range, 15-50 min; P = .027). Future studies are warranted to further investigate potential benefits associated with LFVR in dogs with spontaneous hemoperitoneum.
AuthorsTara N Hammond, Jennifer L Holm, Claire R Sharp
JournalJournal of the American Animal Hospital Association (J Am Anim Hosp Assoc) 2014 May-Jun Vol. 50 Issue 3 Pg. 159-66 ISSN: 1547-3317 [Electronic] United States
PMID24659726 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Hydroxyethyl Starch Derivatives
  • Saline Solution, Hypertonic
Topics
  • Animals
  • Blood Pressure
  • Dog Diseases (therapy)
  • Dogs
  • Fluid Therapy (methods)
  • Hemoperitoneum (therapy, veterinary)
  • Hydroxyethyl Starch Derivatives (administration & dosage)
  • Pilot Projects
  • Resuscitation (methods, veterinary)
  • Saline Solution, Hypertonic (administration & dosage)
  • Shock, Hemorrhagic (therapy, veterinary)
  • Treatment Outcome

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