HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Oncostatin M receptor is a novel therapeutic target in cervical squamous cell carcinoma.

Abstract
Cervical carcinoma is the second most common cause of cancer deaths in women worldwide. Treatments have not changed for decades and survival rates for advanced disease remain low. An exciting new molecular target for the treatment of cervical squamous cell carcinoma (SCC), and possibly for SCCs at other anatomical sites, is the oncostatin M receptor (OSMR). This cell surface cytokine receptor is commonly copy number gained and overexpressed in advanced cervical SCC, changes that are associated with significantly worse clinical outcomes. OSMR overexpression in cervical SCC cells results in enhanced responsiveness to the major ligand oncostatin M (OSM), which induces several pro-malignant effects, including a pro-angiogenic phenotype and increased cell migration and invasiveness. OSMR is a strong candidate for antibody-mediated inhibition, a strategy that has had a major impact on haematological malignancies and various solid tumours such as HER2-positive breast cancers.
AuthorsMaria M Caffarel, Nicholas Coleman
JournalThe Journal of pathology (J Pathol) Vol. 232 Issue 4 Pg. 386-90 (Mar 2014) ISSN: 1096-9896 [Electronic] England
PMID24659184 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Copyright© 2013 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Chemical References
  • Antineoplastic Agents
  • OSMR protein, human
  • Oncostatin M Receptor beta Subunit
Topics
  • Animals
  • Antineoplastic Agents (therapeutic use)
  • Carcinoma, Squamous Cell (drug therapy, genetics, metabolism, pathology)
  • Chromosomes, Human, Pair 5
  • Drug Design
  • Female
  • Gene Amplification
  • Gene Expression Regulation, Neoplastic
  • Genetic Predisposition to Disease
  • Humans
  • Molecular Targeted Therapy
  • Oncostatin M Receptor beta Subunit (antagonists & inhibitors, genetics, metabolism)
  • Phenotype
  • Signal Transduction (drug effects)
  • Up-Regulation
  • Uterine Cervical Neoplasms (drug therapy, genetics, metabolism, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: