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The relationship between monoamine oxidase B (MAOB) A644G polymorphism and Parkinson disease risk: a meta-analysis.

AbstractBACKGROUND AND OBJECTIVES:
Many studies were conducted to assess the relationship between Monoamine oxidase B (MAOB) A644G polymorphism and susceptibility to Parkinson disease (PD). However, the results were inconsistent and inconclusive.
DESIGN AND SETTINGS:
A meta-analysis was conducted from all published studies on the associations between monoamine oxidase B (MAOB) A644G polymorphism and Parkinson disease.
METHODS:
In this present study, the possible relationship between MAOB A644G polymorphism and PD risk was assessed by a meta-analysis. Eligible articles were identified for the period up to March 2013. Pooled odds ratios (OR) with 95% confidence intervals (CI) were appropriately derived from fixed-effects models.
RESULTS:
Twenty case-control studies with a total of 2846 cases and 3508 controls were eligible. In a recessive model, MAOB A644G polymorphism was associated with PD risk (OR=1.32, 95% CI 1.18-1.47, P < .001). Subgroup analyses by ethnicity and gender also found significant relationships between this polymorphism and PD risk.
CONCLUSION:
This meta-analysis suggested that MAOB A644G polymorphism may be associated with PD development.
AuthorsYing Liu, Zhiyun Wang, Benshu Zhang
JournalAnnals of Saudi medicine (Ann Saudi Med) 2014 Jan-Feb Vol. 34 Issue 1 Pg. 12-7 ISSN: 0975-4466 [Electronic] India
PMID24658549 (Publication Type: Journal Article, Meta-Analysis)
Chemical References
  • Monoamine Oxidase
Topics
  • Asian Continental Ancestry Group (genetics)
  • Case-Control Studies
  • European Continental Ancestry Group (genetics)
  • Female
  • Genetic Predisposition to Disease (ethnology)
  • Humans
  • Male
  • Monoamine Oxidase (genetics)
  • Odds Ratio
  • Parkinson Disease (genetics)
  • Polymorphism, Genetic
  • Risk
  • Sex Factors

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