Medicinal plants attract growing interest in the therapeutic management of
Diabetes mellitus. Moringa oleifera is a remarkably nutritious vegetable with several
antioxidant properties. The present study assessed the possible
antioxidant and
antidiabetic effects of an aqueous extract of M. oleifera leaves in treating
streptozotocin-induced diabetic albino rats. The
antidiabetic effects of aqueous extract of M. oleifera leaves were assessed histomorphometrically, ultrastructurally and biochemically. Fasting plasma
glucose (FPG) was monitored and morphometric measurements of β-cells of islets of Langerhans (modified Gomori's
stain) and
collagen fibers (Mallory's
trichrome stain) were performed. The
antioxidant effects of M. oleifera leaves were determined by measuring the
reduced glutathione and lipid peroxidation product,
malondialdehyde, in pancreatic tissue. M. oleifera treatment significantly ameliorated the altered FPG (from 380% to 145%),
reduced glutathione (from 22% to 73%) and
malondialdehyde (from 385% to 186%) compared to control levels. The histopathological damage of islet cells was also markedly reversed. Morphometrically, M. oleifera significantly increased the areas of positive purple modified Gomori stained β-cells (from 60% to 91%) and decreased the area percentage of
collagen fibers (from 199% to 120%) compared to control values. Experimental findings clearly indicate the potential benefits of using the aqueous extract of M. oleifera leaves as a potent
antidiabetic treatment.