Abstract |
Positron-emission tomography (PET) can be used to visualize active stage cancer. Fluorine-18 ([(18)F])-labeled 2-([(18)F])2-deoxy-2-fluoroglucose (([(18)F])-FDG), which accumulates in glucose-dependent tissues, is a good cancer-targeting tracer. However, ([(18)F])-FDG is obscured in glucose-dependent normal tissues. In this study, we assessed the cancer-selective accumulation of zinc-labeled glycoconjugated 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin (ZnGlc1-4), both in vitro and in vivo. Experiments using both normal and cancer cells confirmed the relationship between cancer cell-selective accumulation and the substitution numbers and orientations of glycoconjugated porphyrins. ZnGlctrans-2 accumulated at greater levels in cancer cells compared with other glycoconjugated porphyrins. PET imaging showed that ZnGlctrans-2 accumulated in tumor.
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Authors | Masato Tamura, Hirofumi Matsui, Shiho Hirohara, Kiyomi Kakiuchi, Masao Tanihara, Naruto Takahashi, Kozi Nakai, Yasukazu Kanai, Hiroshi Watabe, Jun Hatazawa |
Journal | Bioorganic & medicinal chemistry
(Bioorg Med Chem)
Vol. 22
Issue 8
Pg. 2563-70
(Apr 15 2014)
ISSN: 1464-3391 [Electronic] England |
PMID | 24656799
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Ltd. All rights reserved. |
Chemical References |
- Porphyrins
- Radiopharmaceuticals
- Zinc Radioisotopes
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Topics |
- Animals
- Cell Line, Tumor
- Magnetic Resonance Imaging
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Neoplasms
(diagnostic imaging)
- Porphyrins
(chemistry, metabolism)
- Positron-Emission Tomography
- Radiopharmaceuticals
(chemistry, metabolism)
- Rats
- Tissue Distribution
- Transplantation, Heterologous
- Zinc Radioisotopes
(chemistry)
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