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Selective accumulation of [⁶²Zn]-labeled glycoconjugated porphyrins as multi-functional positron emission tomography tracers in cancer cells.

Abstract
Positron-emission tomography (PET) can be used to visualize active stage cancer. Fluorine-18 ([(18)F])-labeled 2-([(18)F])2-deoxy-2-fluoroglucose (([(18)F])-FDG), which accumulates in glucose-dependent tissues, is a good cancer-targeting tracer. However, ([(18)F])-FDG is obscured in glucose-dependent normal tissues. In this study, we assessed the cancer-selective accumulation of zinc-labeled glycoconjugated 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin (ZnGlc1-4), both in vitro and in vivo. Experiments using both normal and cancer cells confirmed the relationship between cancer cell-selective accumulation and the substitution numbers and orientations of glycoconjugated porphyrins. ZnGlctrans-2 accumulated at greater levels in cancer cells compared with other glycoconjugated porphyrins. PET imaging showed that ZnGlctrans-2 accumulated in tumor.
AuthorsMasato Tamura, Hirofumi Matsui, Shiho Hirohara, Kiyomi Kakiuchi, Masao Tanihara, Naruto Takahashi, Kozi Nakai, Yasukazu Kanai, Hiroshi Watabe, Jun Hatazawa
JournalBioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 22 Issue 8 Pg. 2563-70 (Apr 15 2014) ISSN: 1464-3391 [Electronic] England
PMID24656799 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2014 Elsevier Ltd. All rights reserved.
Chemical References
  • Porphyrins
  • Radiopharmaceuticals
  • Zinc Radioisotopes
Topics
  • Animals
  • Cell Line, Tumor
  • Magnetic Resonance Imaging
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Neoplasms (diagnostic imaging)
  • Porphyrins (chemistry, metabolism)
  • Positron-Emission Tomography
  • Radiopharmaceuticals (chemistry, metabolism)
  • Rats
  • Tissue Distribution
  • Transplantation, Heterologous
  • Zinc Radioisotopes (chemistry)

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