[Anti-arrhythmic effectiveness of allapinin in ventricular arrhythmia in patients with circulatory failure].

Abstract

Antiarrhythmic efficacy of allapinin was assessed in 15 patients with heart failure combined with ventricular arrhythmias (48 h ECG monitoring). The drug was administered against a background of maintenance therapy with digoxin at a daily dose of 75 mg (digoxin concentration in blood plasma was 1.51 +/- 0.12 ng/ml). The drug was shown to possess marked antiarrhythmic activity causing a decrease of the total number of ventricular extra systoles by an average of 72.3%, group ventricular extrasystoles--by 84.5%. The drug can be recommended in combination with cardiac glycosides to patients with severe heart failure combined with ventricular arrhythmias.

• Authors: V G Naumov, S I Blinov, B G Khodzhakuliev, R S Vangeli
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 60 Issue 8 Pg. 39-41 ( 1988) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Antiaritmicheskaia effektivnost' allapinina pri zheludochkovykh narusheniiakh ritma u bol'nykh s nedostatochnost'iu krovo-obrashcheniia.
• PMID: 2465582 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• allapinin
• Aconitine

Topics

• Aconitine (analogs & derivatives, therapeutic use)
• Aconitum (analogs & derivatives)
• Adult
• Cardiac Complexes, Premature (complications, drug therapy)
• Cardiac Output (drug effects)
• Cardiac Output, Low (complications, drug therapy)
• Clinical Trials as Topic
• Heart Ventricles (drug effects)
• Humans
• Middle Aged