[Hemodynamic effects of mesotrin after its intravenous administration].

Abstract

Mesotrin, a novel Soviet calcium antagonist, given in a single intravenous dose was evaluated for effects on central and peripheral hemodynamic parameters in 27 patients who had no clinical signs of acute or congestive heart failure. The drug used in an antiarrhythmic doses resulted in a substantial decrease in stroke index and cardiac index and increase in total peripheral vascular resistance virtually only by enhancing resistive vascular tone. Mesotrin showed no significant effects on the venous segment of the vascular bed. To attenuate the negative action of the drug on myocardial contractility it was proposed to give it in combination with calcium gluconicum which practically completely abolished the adverse hemodynamic effects of mesotrin.

• Authors: E D Dzhishambaev, V V Panfilov
• Journal: Kardiologiia (Kardiologiia) Vol. 28 Issue 10 Pg. 51-4 (Oct 1988) ISSN: 0022-9040 [Print] Russia (Federation)
• Vernacular Title: Gemodinamicheskie éffekty mezotrina pri vnutrivennom vvedenii.
• PMID: 2465431 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Calcium Channel Blockers
• Diamines
• mesotrin

Topics

• Adult
• Aged
• Calcium Channel Blockers
• Cardiac Complexes, Premature (drug therapy, physiopathology)
• Clinical Trials as Topic
• Depression, Chemical
• Diamines (administration & dosage)
• Female
• Hemodynamics (drug effects)
• Humans
• Injections, Intravenous
• Male
• Middle Aged
• Myocardial Contraction (drug effects)
• Tachycardia, Supraventricular (drug therapy, physiopathology)