Abstract | BACKGROUND: OBJECTIVE: The aim of this study was to evaluate the protective effects of long-term treatment with HLJDT on vascular endothelial function in rats with type 2 diabetes mellitus (T2DM). METHODS: The male T2DM model rats were induced by intraperitoneal injection of low-dose streptozotocin plus a high-fat and high-calorie laboratory diet. The T2DM animals were randomly divided into the T2DM model group, the low-dose HLJDT group (0.42 g/kg/d), and the high-dose HLJDT group (1.25 g/kg/d). RESULTS: Administration of HLJDT (0.42 or 1.25 g/kg/d) for 8 weeks decreased the levels of serum fasting blood glucose, malondialdehyde, and vascular tissue interleukin 6 but raised the level of serum superoxide dismutase compared with the T2DM model group in a dose-dependent manner. In addition, HLJDT treatment restored the impaired endothelial-dependent vascular relaxation in aortic preparations from the T2DM model group in a dose-dependent manner. CONCLUSIONS: Early and long-term treatments with HLJDT could have anti-inflammatory, antioxidant properties and could protect vascular endothelium from the cardiovascular complications associated with T2DM.
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Authors | Quan Yi, Xiao-En He, Kai-Fey Luo, Gen-Shui Zhang, Ying-Hua Liu, Qin Xue, Ning Hou, Wen-Liang Chen, Jian-Dong Luo |
Journal | Current therapeutic research, clinical and experimental
(Curr Ther Res Clin Exp)
Vol. 73
Issue 6
Pg. 174-85
(Dec 2012)
ISSN: 0011-393X [Print] United States |
PMID | 24653519
(Publication Type: Journal Article)
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