Association of FOS-like antigen 1 promoter polymorphism with podocyte foot process effacement in immunoglobulin A nephropathy patients.

Abstract

BACKGROUND:

FOS has been implicated in the progression of renal disease including IgAN. In this study, we investigated whether polymorphisms of FOS family genes [FOS, FOSB, FOS-like antigen 1 (FOSL1), and FOSL2] were associated with immunoglobulin A nephropathy (IgAN) and the clinical phenotypes of IgAN patients.

METHODS:

We genotyped single nucleotide polymorphisms (SNPs) of FOS family genes (rs2239615 and rs7101 for FOS, rs12373539 and rs2282695 for FOSB, rs637571 for FOSL1, and rs925255 for FOSL2) using direct sequencing in 198 IgAN patients and 290 control subjects.

RESULTS:

No SNPs were associated with IgAN; however, in the analysis of clinical phenotypes, we found that rs637571 of FOSL1 was associated with podocyte foot process effacement of IgAN in additive (CT vs. TT vs. CC, P = 0.0031, OR = 2.08, 95% CI = 1.27-3.40) and dominant models (CT/TT vs. CC, P = 0.0034, OR = 2.50, 95% CI = 1.35-4.64). The frequency of genotypes containing the T allele was increased in IgAN patients with podocyte foot process effacement, compared to those without podocyte foot process effacement.

CONCLUSION:

These results suggest that FOSL1 may be related to IgAN severity.

• Authors: Hae Jeong Park, Jong Woo Kim, Byoung-Soo Cho, Joo-Ho Chung
• Journal: Journal of clinical laboratory analysis (J Clin Lab Anal) Vol. 28 Issue 5 Pg. 391-7 (Sep 2014) ISSN: 1098-2825 [Electronic] United States
• PMID: 24652774 (Publication Type: Journal Article)
• Copyright: © 2014 Wiley Periodicals, Inc.

Chemical References

• Proto-Oncogene Proteins c-fos
• fos-related antigen 1

Topics

• Adolescent
• Adult
• Child
• Female
• Gene Frequency
• Genetic Association Studies
• Genetic Predisposition to Disease (genetics)
• Genotype
• Glomerulonephritis, IGA (genetics, pathology)
• Humans
• Male
• Middle Aged
• Podocytes (metabolism)
• Polymorphism, Single Nucleotide (genetics)
• Proto-Oncogene Proteins c-fos (genetics)
• Young Adult