Interferon (IFN)-like antiviral effect is induced by unspecific cross-linking of cell surface receptors.

Abstract

Treatment of human amniotic cells (UAC) with Cytodex 1 (DEAE-dextran) results in the development of an antiviral state of the cells, as proven by studying (i) the cytopathic effect and (ii) [3H]uridine incorporation into the RNA of vesicular stomatitis virus (VSV) after VSV infection. The same treatment transiently triggers the breakdown of inositol phospholipids and activates the translocation of protein kinase C (PKC). On the basis of these data it can be suggested that cross-linking of cell surface receptors by a solid carrier bearing covalently bound positive charges may result in IFN-like effects.

• Authors: G Premecz, A Markovits, G Bagi, T Farkas, I Földes
• Journal: FEBS letters (FEBS Lett) Vol. 243 Issue 2 Pg. 271-4 (Jan 30 1989) ISSN: 0014-5793 [Print] England
• PMID: 2465184 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Dextrans
• Inositol Phosphates
• Membrane Lipids
• RNA, Viral
• Receptors, Immunologic
• Receptors, Interferon
• Cytodex
• Interferons
• Protein Kinase C

Topics

• Antiviral Agents
• Cell Line
• Dextrans (pharmacology)
• Humans
• Inositol Phosphates (metabolism)
• Interferons (physiology)
• Membrane Lipids (metabolism)
• Protein Kinase C (metabolism)
• RNA, Viral (drug effects)
• Receptors, Immunologic (drug effects, physiology)
• Receptors, Interferon
• Vesicular stomatitis Indiana virus (drug effects, immunology)
• Virus Replication (drug effects)