Abstract | PURPOSE: PATIENTS AND METHODS: Women planning to undergo adjuvant chemotherapy for breast cancer and healthy controls underwent neurophysiologic assessments at baseline, during the time of chemotherapy treatment, and at 1 year. Repeated measures analysis of variance was used to analyze the data. RESULTS: Compared with controls, patients reported more subjective fatigue at baseline that increased during chemotherapy and did not entirely resolve by 1 year. Performance on endurance testing was similar in patients versus controls at all time points; however, values of EEG power increased after a physical task in patients during chemotherapy but not controls. Compared with controls, subjective mental fatigue was similar for patients at baseline and 1 year but worsened during chemotherapy. Patients performed similarly to controls on formal cognitive testing at all time points, but EEG activity after the cognitive task was increased in patients only during chemotherapy. CONCLUSION:
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Authors | Halle C F Moore, Michael W Parsons, Guang H Yue, Lisa A Rybicki, Wlodzimierz Siemionow |
Journal | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
(Support Care Cancer)
Vol. 22
Issue 8
Pg. 2127-31
(Aug 2014)
ISSN: 1433-7339 [Electronic] Germany |
PMID | 24647490
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Breast Neoplasms
(drug therapy, psychology)
- Case-Control Studies
- Chemotherapy, Adjuvant
- Cognition Disorders
(chemically induced, diagnosis)
- Electroencephalography
(methods)
- Fatigue
(chemically induced, diagnosis)
- Female
- Humans
- Middle Aged
- Neurologic Examination
(methods)
- Pilot Projects
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