A snapshot of challenges and solutions in cancer drug development and therapy.

Abstract

Cancer chemotherapy has transitioned from the use of cytotoxic drugs to the era of agents with an apparent selectivity for a cancer-specific target. The past decade has provided evidence that therapy with such agents can be curative in subsets of patients. It is anticipated that incorporation of pharmacological principles for novel therapeutics will result in further refinement of outcome measures as well as the discovery of new treatment modalities for multiple malignant diseases.

• Authors: M A Phelps, A Sparreboom
• Journal: Clinical pharmacology and therapeutics (Clin Pharmacol Ther) Vol. 95 Issue 4 Pg. 341-6 (Apr 2014) ISSN: 1532-6535 [Electronic] United States
• PMID: 24646480 (Publication Type: Editorial, Introductory Journal Article)

Chemical References

• Antineoplastic Agents

Topics

• Antineoplastic Agents (pharmacology)
• Drug Design
• Humans
• Molecular Targeted Therapy
• Neoplasms (drug therapy, pathology)
• Outcome Assessment, Health Care