Insulin-like growth factor-i and risk of differentiated thyroid carcinoma in the European prospective investigation into cancer and nutrition.

Abstract

BACKGROUND:

Little is known about the causes of thyroid cancer, but insulin-like growth factor-I (IGF-I) might play an important role in its development due to its mitogenic and antiapoptotic properties.

METHODS:

This study prospectively investigated the association between serum IGF-I concentrations and risk of differentiated thyroid carcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. The 345 incident cases of differentiated thyroid carcinoma were individually matched to 735 controls by study center, sex and age, date, time, and fasting status at blood collection, follow-up duration, and for women menopausal status, use of exogenous hormones, and phase of menstrual cycle at blood collection. Serum IGF-I concentrations were measured by immunoassay, and risk of differentiated thyroid cancer in relation to IGF-I concentration was estimated using conditional logistic regression.

RESULTS:

There was a positive association between IGF-I concentrations and risk of differentiated thyroid carcinoma: the OR for a doubling in IGF-I concentration was 1.48 (95% confidence interval, 1.06-2.08; Ptrend = 0.02). The positive association with IGF-I was stable over time between blood collection and cancer diagnosis.

CONCLUSION:

These findings suggest that IGF-I concentrations may be positively associated with risk of differentiated thyroid carcinoma.

IMPACT:

This study provides the first prospective evidence of a potential association between circulating IGF-I concentrations and risk of differentiated thyroid carcinoma and may prompt the further investigations needed to confirm the association.

• Authors: Julie A Schmidt, Naomi E Allen, Martin Almquist, Silvia Franceschi, Sabina Rinaldi, Sarah J Tipper, Konstantinos K Tsilidis, Elisabete Weiderpass, Kim Overvad, Anne Tjønneland, Marie-Christine Boutron-Ruault, Laure Dossus, Sylvie Mesrine, Rudolf Kaaks, Annekatrin Lukanova, Heiner Boeing, Pagona Lagiou, Dimitrios Trichopoulos, Antonia Trichopoulou, Domenico Palli, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Roberto Zanetti, H Bas Bueno-de-Mesquita, Petra H Peeters, Eiliv Lund, Virginia Menéndez, Antonio Agudo, María-José Sánchez, Maria-Dolores Chirlaque, Eva Ardanaz, Nerea Larrañaga, Joakim Hennings, Maria Sandström, Kay-Tee Khaw, Nick Wareham, Isabelle Romieu, Marc J Gunter, Elio Riboli, Timothy J Key, Ruth C Travis
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 23 Issue 6 Pg. 976-85 (Jun 2014) ISSN: 1538-7755 [Electronic] United States
• PMID: 24646451 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: ©2014 American Association for Cancer Research.

Chemical References

• Insulin-Like Growth Factor I

Topics

• Adult
• Aged
• Case-Control Studies
• Europe
• Female
• Humans
• Insulin-Like Growth Factor I (metabolism)
• Male
• Middle Aged
• Nutrition Assessment
• Prospective Studies
• Risk Factors
• Thyroid Neoplasms (etiology)