In vitro and in vivo antitumor evaluation of berbamine for lung cancer treatment.

Abstract

PURPOSE:

Lung cancer, one of the most frequently diagnosed cancers in the world, is characterized by relatively high morbidity and mortality. Berbamine (BER) has been initially reported to exert anti-proliferative effects against a series of cancers.

METHODS:

In this study the in vitro cytotoxicity of BER was measured by MTT assay. In vivo anti-cancer efficacy of BER was assessed in A549 xenografts.

RESULTS:

Cytotoxicity tests showed dose-dependent cell growth inhibition effects of BER against A549 cells. Moreover, BER significantly reduced the growth of lung cancer in a dose-dependent manner in nude mice with prolonged survival time.

CONCLUSION:

Therefore, BER might be in herbal medicine for cancer therapy and further efforts are needed to explore therapeutic strategies.

• Authors: Zhi-Bo Hou, Kai-Jin Lu, Xiao-Li Wu, Cong Chen, Xin-En Huang, Hai-Tao Yin
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 15 Issue 4 Pg. 1767-9 ( 2014) ISSN: 2476-762X [Electronic] Thailand
• PMID: 24641406 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antineoplastic Agents
• Benzylisoquinolines
• Calcium Channel Blockers
• berbamine

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Antineoplastic Agents (therapeutic use)
• Benzylisoquinolines (therapeutic use)
• Calcium Channel Blockers (therapeutic use)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Cell Survival (drug effects)
• Female
• Humans
• Lung Neoplasms (drug therapy, mortality)
• Male
• Mice
• Mice, Nude
• Transplantation, Heterologous
• Xenograft Model Antitumor Assays