Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Hemerocallis citrina, a traditional herbal medicine, has been used for the improvement of behavioral and emotional status in Eastern-Asia countries. Previous studies in our laboratory demonstrated that ethanol extracts from Hemerocallis citrina ( HCE) enhanced monoamines and brain-derived neurotrophic factor ( BDNF) in depression-like model of rodents. MATERIALS AND METHODS: The present study extends earlier works on the role of anti- inflammation in regulating the antidepressant-like actions of HCE in rats exposed to chronic unpredictable mild stress (CUMS). Frontal cortex and hippocampal proinflammatory cytokines levels and indoleamine 2,3-dioxygenase (IDO) activity were measured after 4-week HCE treatment in the CUMS an control rats. RESULTS: CONCLUSIONS: Combining with our previous studies, our present finding suggests that the anti-inflammatory property of HCE might play a crucial role in its antidepressant-like effect through, at least in part, the restoration or improvement of monoaminergic and neurotrophin systems.
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Authors | Xiao-Long Liu, Liu Luo, Bin-Bin Liu, Jing Li, Di Geng, Qing Liu, Li-Tao Yi |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 153
Issue 2
Pg. 484-90
(Apr 28 2014)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 24632017
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Cytokines
- Indoleamine-Pyrrole 2,3,-Dioxygenase
- Inflammation Mediators
- Plant Extracts
- Ethanol
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Topics |
- Animals
- Cytokines
(antagonists & inhibitors, biosynthesis)
- Ethanol
(isolation & purification)
- Flowers
- Hemerocallis
- Indoleamine-Pyrrole 2,3,-Dioxygenase
(antagonists & inhibitors, biosynthesis)
- Inflammation Mediators
(antagonists & inhibitors, metabolism)
- Male
- Plant Extracts
(isolation & purification, pharmacology)
- Rats
- Rats, Wistar
- Up-Regulation
(drug effects, physiology)
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