Ethanol extracts from Hemerocallis citrina attenuate the upregulation of proinflammatory cytokines and indoleamine 2,3-dioxygenase in rats.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Hemerocallis citrina, a traditional herbal medicine, has been used for the improvement of behavioral and emotional status in Eastern-Asia countries. Previous studies in our laboratory demonstrated that ethanol extracts from Hemerocallis citrina (HCE) enhanced monoamines and brain-derived neurotrophic factor (BDNF) in depression-like model of rodents.

MATERIALS AND METHODS:

The present study extends earlier works on the role of anti-inflammation in regulating the antidepressant-like actions of HCE in rats exposed to chronic unpredictable mild stress (CUMS). Frontal cortex and hippocampal proinflammatory cytokines levels and indoleamine 2,3-dioxygenase (IDO) activity were measured after 4-week HCE treatment in the CUMS an control rats.

RESULTS:

Chronic administration of HCE reversed the decreased sucrose preference in sucrose preference test. In addition, we also found that HCE inhibited interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) expression, as well as IDO activity in frontal cortex and hippocampus, which were increased in rats exposed to CUMS.

CONCLUSIONS:

Combining with our previous studies, our present finding suggests that the anti-inflammatory property of HCE might play a crucial role in its antidepressant-like effect through, at least in part, the restoration or improvement of monoaminergic and neurotrophin systems.

• Authors: Xiao-Long Liu, Liu Luo, Bin-Bin Liu, Jing Li, Di Geng, Qing Liu, Li-Tao Yi
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 153 Issue 2 Pg. 484-90 (Apr 28 2014) ISSN: 1872-7573 [Electronic] Ireland
• PMID: 24632017 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Cytokines
• Indoleamine-Pyrrole 2,3,-Dioxygenase
• Inflammation Mediators
• Plant Extracts
• Ethanol

Topics

• Animals
• Cytokines (antagonists & inhibitors, biosynthesis)
• Ethanol (isolation & purification)
• Flowers
• Hemerocallis
• Indoleamine-Pyrrole 2,3,-Dioxygenase (antagonists & inhibitors, biosynthesis)
• Inflammation Mediators (antagonists & inhibitors, metabolism)
• Male
• Plant Extracts (isolation & purification, pharmacology)
• Rats
• Rats, Wistar
• Up-Regulation (drug effects, physiology)