[The pharmacokinetics and pharmacodynamics of the new Soviet anti-arrhythmia preparation allapinin].

Abstract

Pharmacokinetics and pharmacodynamics of a new antiarrhythmic drug allapinin was studied in patients with frequent ventricular and supraventricular extrasystoles. The technique of determining allapinin by high performance liquid chromatography is described. Intravenous administration of the drug in a dose of 20 mg was shown to be effective in 50% of patients.

• Authors: A Abdalla, V A Rulin, N A Mazur, S I Chikovani
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1988 Sep-Oct Vol. 51 Issue 5 Pg. 47-9 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Farmakokinetika i farmakodinamika novogo otechesvennogo antiaritmicheskogo preparata allapinina.
• PMID: 2463182 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• allapinin
• Aconitine

Topics

• Aconitine (analogs & derivatives, pharmacokinetics, pharmacology, therapeutic use)
• Aconitum (analogs & derivatives)
• Cardiac Complexes, Premature (blood, drug therapy, physiopathology)
• Chromatography, High Pressure Liquid (instrumentation, methods)
• Coronary Disease (blood, drug therapy, physiopathology)
• Drug Evaluation
• Electrocardiography
• Heart Rate (drug effects)
• Humans
• Time Factors