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The role of sex hormones in induced-systemic inflammation in female albino rats.

AbstractUNLABELLED:
Estrogen (E(2)) and progesterone (P) hormones have a pro-inflammatory and an anti-inflammatory role under different conditions. The current study explored this phenomenon in the context of septic inflammation.
MATERIALS AND METHODS:
This study involved 48 female albino rats. E(2) (4 mg/100 g body weight (b.w.) and P (5 mg/kg b.w.) were administered to ovariectomized (OVX) rats after systemic inflammation (SI) induced by puncturing the caecum I cm from its end with a single hole by using a 21-gauge needle. Key indices of inflammation and apoptosis were evaluated.
RESULTS:
OVX animals subjected to SI showed significantly increased levels of serum tumor necrosis factor-alpha (TNF-u), C reactive protein (CRP) and alanine aminotransferase (ALT). They also showed higher levels of expression of the enzyme inducible nitric oxide synthase (iN OS); 312 ± 43 mg/ml; in the liver, and the activity of both cyclooxygenase 2 (COX-2); 59.4 ± 3.2 U/ml; and caspase 3 enzymes; 6.3 ± 0.54 ng/ml; when compared to non-OVX animals subjected to (SI), (180 ± 3 mg/ml, 16.4 ± 1.69 U/ml, 0.98 ± 0.23 ng/ml respectively). Administration of E(2) resulted in a significant reduction of all serum and liver tissue parameters of inflammation (e.g.decreased iNOS; 193 ± 28 mg/ml and COX-2; 27.6 ± 3.91 U/ml) and decreased apoptosis (Caspase 3; 1.18 ± 0.21 ng/ml). In contrast, OVX animals injected with P before induction of SI showed a significant rise of all measured parameters.
CONCLUSIONS:
E(2) and Pin physiological levels have contrasting though complementary roles in regulation of the immune system possibly allowing a limited inflammatory response while preventing excessive damage to the tissues.
AuthorsA Hassouna, E Obaia, S Marzouk, M Rateb, Mohamed Haidara
JournalActa physiologica Hungarica (Acta Physiol Hung) Vol. 101 Issue 1 Pg. 112-27 (Mar 2014) ISSN: 0231-424X [Print] Hungary
PMID24631798 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents
  • Carrier Proteins
  • Crp protein, rat
  • Inflammation Mediators
  • Tumor Necrosis Factor-alpha
  • Progesterone
  • Estradiol
  • Nitric Oxide Synthase Type II
  • Nos2 protein, rat
  • Cyclooxygenase 2
  • Ptgs2 protein, rat
  • Alanine Transaminase
  • Casp3 protein, rat
  • Caspase 3
Topics
  • Alanine Transaminase (blood)
  • Animals
  • Anti-Inflammatory Agents (administration & dosage)
  • Apoptosis
  • Carrier Proteins (blood)
  • Caspase 3 (metabolism)
  • Cecum (microbiology, surgery)
  • Cyclooxygenase 2 (metabolism)
  • Disease Models, Animal
  • Estradiol (administration & dosage, blood, metabolism)
  • Estrogen Replacement Therapy
  • Female
  • Inflammation (metabolism, microbiology, pathology, prevention & control)
  • Inflammation Mediators (blood, metabolism)
  • Liver (metabolism, pathology)
  • Nitric Oxide Synthase Type II (metabolism)
  • Ovariectomy
  • Progesterone (administration & dosage, blood, metabolism)
  • Punctures
  • Rats
  • Tumor Necrosis Factor-alpha (blood)

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