The dynamics of serum anti-Mullerian-hormone levels during controlled ovarian hyperstimulation with GnRH-antagonist short protocol in polycystic ovary syndrome and low responders.

Abstract

OBJECTIVE:

To determine whether the decrease in AMH levels during ovarian hyperstimulation for IVF occurs in patients with polycystic ovary syndrome (PCOS) and patients with low ovarian reserve (LOR), as in normal cycling women.

STUDY DESIGN:

A cohort of 22 infertile patients treated in a single tertiary center with a GnRH-antagonist short protocol for IVF were prospectively included and divided into three groups: PCOS with hyperandrogenism (n=7), LOR (n=8) and control (n=7). Serum AMH levels were measured before and during FSH treatment, on the day of HCG administration, at the mid-luteal phase, and 14 days after embryo transfer. The three groups were compared using an ANOVA model in the case of continuous data and with Fisher's exact test when the data were discrete.

RESULTS:

In the PCOS group, AMH levels increased at the beginning of the stimulation, but later decreased, until the mid-luteal stage. In the other two groups, AMH levels decreased throughout ovarian stimulation until the mid-luteal stage. In all groups, AMH levels returned to baseline levels two weeks after HCG administration, regardless of treatment outcome (pregnancy or not).

CONCLUSIONS:

AMH levels decline during controlled ovarian hyperstimulation with a GnRH-antagonist short protocol in women with low and normal ovarian reserves. In contrast, in women with PCOS, an increase in AMH levels precedes this decline. These findings may support the hypothesis that androgens may play a role in AMH regulation in women.

• Authors: Amir Weintraub, Ehud J Margalioth, Avraham Ben Chetrit, Michael Gal, Doron Goldberg, Sara Alerhand, Talia Eldar-Geva
• Journal: European journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 176 Pg. 163-7 (May 2014) ISSN: 1872-7654 [Electronic] Ireland
• PMID: 24630573 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Gonadotropin-Releasing Hormone
• Anti-Mullerian Hormone
• cetrorelix

Topics

• Adult
• Anti-Mullerian Hormone (blood, metabolism)
• Female
• Fertilization in Vitro (methods)
• Gonadotropin-Releasing Hormone (administration & dosage, analogs & derivatives, antagonists & inhibitors)
• Humans
• Hyperandrogenism
• Infertility, Female (therapy)
• Luteal Phase
• Ovarian Follicle
• Ovarian Reserve
• Ovulation Induction (methods)
• Polycystic Ovary Syndrome (blood)