Abstract | BACKGROUND: GastroGard, an omeprazole powder paste formulation, is considered the standard treatment for gastric ulcers in horses and is highly effective. Gastrozol, an enteric-coated omeprazole formulation for horses, has recently become available, but efficacy data are controversial and sparse. OBJECTIVES: ANIMALS: 40 horses; 9.5 ± 4.6 years; 491 ± 135 kg. METHODS: Prospective, randomized, blinded study. Horses with an ulcer score ≥1 (Equine Gastric Ulcer Council) were randomly divided into 2 groups and treated for 2 weeks each with GastroGard followed by Gastrozol (A) or vice versa (B). After 2 and 4 weeks, scoring was repeated and compared with baseline. Plasma omeprazole concentrations were measured on the first day of treatment after administration of GastroGard (n = 5) or Gastrozol (n = 5). RESULTS: Compared with baseline (squamous score (A) 1.65 ± 0.11, (B) 1.98 ± 0.11), ulcer scores at 2 weeks ((A) 0.89 ± 0.11, (B) 1.01 ± 0.11) and 4 weeks ((A) 1.10 ± 0.12, (B) 0.80 ± 0.12) had significantly decreased in both groups (P < .001), independent of treatment (P = .7). Plasma omeprazole concentrations were significantly higher after GastroGard compared with Gastrozol administration (AUCGG = 2856 (1405-4576) ng/mL × h, AUCGZ = 604 (430-1609) ng/mL × h; P = .03). The bioavailability for Gastrozol was 1.26 (95% CI 0.56-2.81) times higher than for GastroGard. CONCLUSIONS AND CLINICAL IMPORTANCE: Both Gastrozol and GastroGard, combined with appropriate environmental changes, promote healing of gastric ulcers in horses. However, despite enteric coating of Gastrozol, plasma omeprazole concentrations after single labeled doses were significantly higher with GastroGard.
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Authors | K Birkmann, H K Junge, E Maischberger, M Wehrli Eser, C C Schwarzwald |
Journal | Journal of veterinary internal medicine
(J Vet Intern Med)
2014 May-Jun
Vol. 28
Issue 3
Pg. 925-33
ISSN: 1939-1676 [Electronic] United States |
PMID | 24628650
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2014 by the American College of Veterinary Internal Medicine. |
Chemical References |
- Anti-Ulcer Agents
- Ointments
- Powders
- Tablets, Enteric-Coated
- Omeprazole
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Topics |
- Animals
- Anti-Ulcer Agents
(administration & dosage, blood, pharmacokinetics, therapeutic use)
- Female
- Horse Diseases
(drug therapy)
- Horses
- Male
- Ointments
(therapeutic use)
- Omeprazole
(administration & dosage, blood, pharmacokinetics, therapeutic use)
- Powders
(therapeutic use)
- Stomach Ulcer
(drug therapy, veterinary)
- Tablets, Enteric-Coated
(therapeutic use)
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