Modifying effect of dual antiplatelet therapy on incidence of stent thrombosis according to implanted drug-eluting stent type.

Abstract

AIM:

To investigate the putative modifying effect of dual antiplatelet therapy (DAPT) use on the incidence of stent thrombosis at 3 years in patients randomized to Endeavor zotarolimus-eluting stent (E-ZES) or Cypher sirolimus-eluting stent (C-SES).

METHODS AND RESULTS:

Of 8709 patients in PROTECT, 4357 were randomized to E-ZES and 4352 to C-SES. Aspirin was to be given indefinitely, and clopidogrel/ticlopidine for ≥ 3 months or up to 12 months after implantation. Main outcome measures were definite or probable stent thrombosis at 3 years. Multivariable Cox regression analysis was applied, with stent type, DAPT, and their interaction as the main outcome determinants. Dual antiplatelet therapy adherence remained the same in the E-ZES and C-SES groups (79.6% at 1 year, 32.8% at 2 years, and 21.6% at 3 years). We observed a statistically significant (P = 0.0052) heterogeneity in treatment effect of stent type in relation to DAPT. In the absence of DAPT, stent thrombosis was lower with E-ZES vs. C-SES (adjusted hazard ratio 0.38, 95% confidence interval 0.19, 0.75; P = 0.0056). In the presence of DAPT, no difference was found (1.18; 0.79, 1.77; P = 0.43).

CONCLUSION:

A strong interaction was observed between drug-eluting stent type and DAPT use, most likely prompted by the vascular healing response induced by the implanted DES system. These results suggest that the incidence of stent thrombosis in DES trials should not be evaluated independently of DAPT use, and the optimal duration of DAPT will likely depend upon stent type (Clinicaltrials.gov number NCT00476957).

• Authors: Edoardo Camenzind, Eric Boersma, William Wijns, Laura Mauri, Tessa Rademaker-Havinga, Farzin Fath Ordoubadi, Maarten J Suttorp, Mohammad Al Kurdi, Ph Gabriel Steg, PROTECT Steering Committee and Investigators
• Journal: European heart journal (Eur Heart J) Vol. 35 Issue 29 Pg. 1932-48 (Aug 01 2014) ISSN: 1522-9645 [Electronic] England
• PMID: 24627416 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: [email protected].

Chemical References

• Fibrinolytic Agents
• Platelet Aggregation Inhibitors
• Clopidogrel
• zotarolimus
• Ticlopidine
• Aspirin
• Sirolimus

Topics

• Aspirin (therapeutic use)
• Blood Vessel Prosthesis
• Clopidogrel
• Coronary Restenosis (prevention & control)
• Coronary Thrombosis (prevention & control)
• Drug-Eluting Stents
• Female
• Fibrinolytic Agents (therapeutic use)
• Graft Occlusion, Vascular (prevention & control)
• Humans
• Male
• Middle Aged
• Platelet Aggregation Inhibitors (therapeutic use)
• Prospective Studies
• Prosthesis Failure (adverse effects)
• Sirolimus (analogs & derivatives, therapeutic use)
• Ticlopidine (analogs & derivatives, therapeutic use)
• Treatment Outcome