[A comparison of the sialyl SSEA-1 antigen and CEA in the histology of malignant mesothelioma, with special reference to adenocarcinoma of the lung].

Abstract

Tumor tissues obtained from 5 cases of malignant mesothelioma and from 5 cases of primary adenocarcinoma of the lung have been studied on staining with the sialyl SSEA-1 antibody by the PAP method. Results in all cases of a malignant mesothelioma (both Epithelioid and Sarcomatous pattern) were absolutely negative. All cases of lung cancer, however, were positive, though in differing degrees. In evaluating a malignant mesothelioma, many reports have indicated that the negativity of CEA staining is useful in achieving the differential diagnosis from lung cancer. The sensitivity of the staining by sialyl SSEA-1 was found to be far better than that of CEA in examining either malignant mesothelioma or lung cancer. Thus, we found that not only CEA but also sialyl SSEA-1 antigen staining was useful for the diagnosing of a malignant mesothelioma.

• Authors: T Kishimoto, K Okada, F Shimamoto, T Sato, T Ono
• Journal: Gan no rinsho. Japan journal of cancer clinics (Gan No Rinsho) Vol. 34 Issue 14 Pg. 1951-5 (Nov 1988) ISSN: 0021-4949 [Print] Japan
• PMID: 2462647 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antigens, Neoplasm
• Carcinoembryonic Antigen
• Glycolipids
• Lewis X Antigen

Topics

• Adenocarcinoma (immunology, pathology)
• Aged
• Aged, 80 and over
• Antigens, Neoplasm (analysis)
• Carcinoembryonic Antigen (analysis)
• Diagnosis, Differential
• Female
• Glycolipids (analysis)
• Humans
• Lewis X Antigen
• Lung Neoplasms (immunology, pathology)
• Male
• Mesothelioma (immunology, pathology)
• Staining and Labeling (methods)