One-pot template-free synthesis of NaYF4 upconversion hollow nanospheres for bioimaging and drug delivery.

Abstract

Hollow-structured nanomaterials with fluorescent properties are extremely attractive for image-guided cancer therapy. In this paper, sub-100 nm and hydrophilic NaYF4 upconversion (UC) hollow nanospheres (HNSs) with multicolor UC luminescence and drug-delivery properties were successfully prepared by a facile one-pot template-free hydrothermal route using polyetherimide (PEI) polymer as the stabilizing agent. XRD, SEM, TEM, and N2-adsorption/desorption were used to characterize the as-obtained products. The growth mechanism of the HNSs has been systematically investigated on the basis of the Ostwald ripening. Under 980 nm excitation, UC emissions of HNSs can be tuned by a simple change of the concentration or combination of various upconverters. As a result, the PEI-coated HNSs could be used as efficient probes for in vitro upconversion luminescence (UCL) cell imaging. Furthermore, a doxorubicin storage/release behavior and cancer-cell-killing ability investigation reveal that the product has the potential to be a drug carrier for cancer therapy.

• Authors: Gan Tian, Longsheng Duan, Xiao Zhang, Wenyan Yin, Liang Yan, Liangjun Zhou, Xiaodong Liu, Xiaopeng Zheng, Jinxia Li, Zhanjun Gu, Yuliang Zhao
• Journal: Chemistry, an Asian journal (Chem Asian J) Vol. 9 Issue 6 Pg. 1655-62 (Jun 2014) ISSN: 1861-471X [Electronic] Germany
• PMID: 24623524 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Antineoplastic Agents
• Contrast Media
• Drug Carriers
• sodium yttriumtetrafluoride
• Yttrium
• Doxorubicin
• Fluorides

Topics

• Antineoplastic Agents (administration & dosage, pharmacokinetics, pharmacology)
• Cell Survival (drug effects)
• Contrast Media (chemical synthesis, chemistry, toxicity)
• Doxorubicin (administration & dosage, pharmacokinetics, pharmacology)
• Drug Carriers (chemical synthesis, chemistry, toxicity)
• Drug Liberation
• Fluorides (chemical synthesis, chemistry, toxicity)
• Humans
• Hydrophobic and Hydrophilic Interactions
• KB Cells
• Luminescent Measurements
• Microscopy, Electron, Transmission
• Microscopy, Fluorescence
• Nanospheres (chemistry)
• Surface Properties
• Yttrium (chemistry, toxicity)