Insulin sensitivity and albuminuria: the RISC study.

Abstract

OBJECTIVE:

Accumulating evidence suggests an association between insulin sensitivity and albuminuria, which, even in the normal range, is a risk factor for cardiovascular diseases. We evaluated whether insulin sensitivity is associated with albuminuria in healthy subjects.

RESEARCH DESIGN AND METHODS:

We investigated 1,415 healthy, nondiabetic participants (mean age 43.9 ± 8.3 years; 54.3% women) from the RISC (Relationship between Insulin Sensitivity and Cardiovascular Disease) study, of whom 852 participated in a follow-up examination after 3 years. At baseline, insulin sensitivity was assessed by hyperinsulinemic-euglycemic clamps, expressed as the M/I value. Oral glucose tolerance test-based insulin sensitivity (OGIS), homeostasis model assessment of insulin resistance (HOMA-IR), and urinary albumin-to-creatinine ratio (UACR) were determined at baseline and follow-up.

RESULTS:

Microalbuminuria (UACR ≥30 mg/g) was present in fewer than 2% at either study visit. After multivariate adjustments, there was no cross-sectional association between UACR and any measure of insulin sensitivity. Neither OGIS nor HOMA-IR was significantly associated with follow-up UACR, but in a multivariate regression analysis, baseline M/I emerged as an independent predictor of UACR at follow-up (β-coefficient -0.14; P = 0.001).

CONCLUSIONS:

In healthy middle-aged adults, reduced insulin sensitivity, assessed by hyperinsulinemic-euglycemic clamp, is continuously associated with a greater risk of increasing albuminuria. This finding suggests that reduced insulin sensitivity either is simply related to or might causally contribute to the initial pathogenesis of albuminuria.

• Authors: Stefan Pilz, Femke Rutters, Giel Nijpels, Coen D A Stehouwer, Kurt Højlund, John J Nolan, Beverley Balkau, Jacqueline M Dekker, RISC Investigators
• Journal: Diabetes care (Diabetes Care) Vol. 37 Issue 6 Pg. 1597-603 (Jun 2014) ISSN: 1935-5548 [Electronic] United States
• PMID: 24623021 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 by the American Diabetes Association.

Chemical References

• Insulin
• Creatinine

Topics

• Adult
• Albuminuria (epidemiology, physiopathology)
• Cardiovascular Diseases (epidemiology)
• Creatinine (urine)
• Cross-Sectional Studies
• Europe (epidemiology)
• Female
• Follow-Up Studies
• Glucose Clamp Technique
• Glucose Tolerance Test
• Humans
• Hyperinsulinism (diagnosis)
• Incidence
• Insulin (metabolism)
• Insulin Resistance
• Insulin Secretion
• Male
• Middle Aged
• Multivariate Analysis
• Prospective Studies
• Risk Factors