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Luliconazole: a review of a new antifungal agent for the topical treatment of onychomycosis.

Abstract
Luliconazole is a novel, broad-spectrum, imidazole antifungal under development in the USA as a treatment for dermatophytic skin and nail infections. In vitro, luliconazole is one of the most potent antifungal agents against filamentous fungi including dermatophytes. Luliconazole has been formulated in a 10% solution with unique molecular properties, which allow it to penetrate the nail plate and rapidly achieve fungicidal levels in the nail unit. These properties make luliconazole a potent compound in the treatment of onychomycosis. This article reviews the development of luliconazole solution, 10% its molecular properties, preclinical and clinical data and its future perspectives for the treatment of fungal infections.
AuthorsRichard K Scher, Norifumi Nakamura, Amir Tavakkol
JournalMycoses (Mycoses) Vol. 57 Issue 7 Pg. 389-93 (Jul 2014) ISSN: 1439-0507 [Electronic] Germany
PMID24621346 (Publication Type: Journal Article, Review)
Copyright© 2014 Blackwell Verlag GmbH.
Chemical References
  • Antifungal Agents
  • Imidazoles
  • Pharmaceutical Solutions
  • luliconazole
Topics
  • Administration, Topical
  • Antifungal Agents (administration & dosage)
  • Foot Dermatoses (drug therapy)
  • Humans
  • Imidazoles (administration & dosage)
  • Onychomycosis (drug therapy)
  • Pharmaceutical Solutions (administration & dosage)

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