Abstract |
Luliconazole is a novel, broad-spectrum, imidazole antifungal under development in the USA as a treatment for dermatophytic skin and nail infections. In vitro, luliconazole is one of the most potent antifungal agents against filamentous fungi including dermatophytes. Luliconazole has been formulated in a 10% solution with unique molecular properties, which allow it to penetrate the nail plate and rapidly achieve fungicidal levels in the nail unit. These properties make luliconazole a potent compound in the treatment of onychomycosis. This article reviews the development of luliconazole solution, 10% its molecular properties, preclinical and clinical data and its future perspectives for the treatment of fungal infections.
|
Authors | Richard K Scher, Norifumi Nakamura, Amir Tavakkol |
Journal | Mycoses
(Mycoses)
Vol. 57
Issue 7
Pg. 389-93
(Jul 2014)
ISSN: 1439-0507 [Electronic] Germany |
PMID | 24621346
(Publication Type: Journal Article, Review)
|
Copyright | © 2014 Blackwell Verlag GmbH. |
Chemical References |
- Antifungal Agents
- Imidazoles
- Pharmaceutical Solutions
- luliconazole
|
Topics |
- Administration, Topical
- Antifungal Agents
(administration & dosage)
- Foot Dermatoses
(drug therapy)
- Humans
- Imidazoles
(administration & dosage)
- Onychomycosis
(drug therapy)
- Pharmaceutical Solutions
(administration & dosage)
|