A dual-targeting upconversion nanoplatform for two-color fluorescence imaging-guided photodynamic therapy.

Abstract

The targetability of a theranostic probe is one of the keys to assuring its theranostic efficiency. Here we show the design and fabrication of a dual-targeting upconversion nanoplatform for two-color fluorescence imaging-guided photodynamic therapy (PDT). The nanoplatform was prepared from 3-aminophenylboronic acid functionalized upconversion nanocrystals (APBA-UCNPs) and hyaluronated fullerene (HAC60) via a specific diol-borate condensation. The two specific ligands of aminophenylboronic acid and hyaluronic acid provide synergistic targeting effects, high targetability, and hence a dramatically elevated uptake of the nanoplatform by cancer cells. The high generation yield of (1)O2 due to multiplexed Förster resonance energy transfer between APBA-UCNPs (donor) and HAC60 (acceptor) allows effective therapy. The present nanoplatform shows great potential for highly selective tumor-targeted imaging-guided PDT.

• Authors: Xu Wang, Cheng-Xiong Yang, Jia-Tong Chen, Xiu-Ping Yan
• Journal: Analytical chemistry (Anal Chem) Vol. 86 Issue 7 Pg. 3263-7 (Apr 01 2014) ISSN: 1520-6882 [Electronic] United States
• PMID: 24621215 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Animals
• Color
• Fluorescence Resonance Energy Transfer
• Microscopy, Electron, Transmission
• Nanotechnology
• PC12 Cells
• Photochemotherapy
• Proton Magnetic Resonance Spectroscopy
• Rats
• Spectroscopy, Fourier Transform Infrared