Epidemiological genetics and meta-analysis of a polymorphism at codon 129 of the PRNP gene in Alzheimer's disease in Brazil.

Abstract

The polymorphism at codon 129 of the prion protein gene (PRNP) is a major risk factor for Creutzfeldt-Jakob disease (CJD). Several authors reported neuropathological and clinical overlapping between CJD and Alzheimer's disease (AD), with a few association studies generating conflicting results. To investigate the distribution of this polymorphism in AD, we selected 58 patients with probable AD and 73 controls from a Brazilian population. There was no association between the PRNP polymorphism at codon 129 and AD. Our meta-analysis (performed using Alzgene; http://www.alzgene.org) along with previous studies conducted in Brazil demonstrated a negative association.

• Authors: Lylyan Fragoso Pimentel, José Eriton Gomes da Cunha, Renato Lírio Morelato, Flávia de Paula, João Ricardo Mendes de Oliveira
• Journal: Neurological research (Neurol Res) Vol. 36 Issue 9 Pg. 775-8 (Sep 2014) ISSN: 1743-1328 [Electronic] England
• PMID: 24620982 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• Codon
• PRNP protein, human
• Prion Proteins
• Prions

Topics

• Aged
• Alzheimer Disease (epidemiology, genetics)
• Brazil (epidemiology)
• Codon
• Female
• Genotyping Techniques
• Humans
• Male
• Polymerase Chain Reaction
• Polymorphism, Genetic
• Prion Proteins
• Prions (genetics)